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Does nabumetone have any side effects?
Nabumetone helps relieve pain associated with rheumatoid arthritis or osteoarthritis. It can be taken as a single daily dose and appears less likely to cause stomach-related side effects than some other NSAIDs. 5.
What is nabumetone used for?
Nabumetone helps relieve pain and inflammation by blocking the effects of COX enzymes. This prevents prostaglandin synthesis (prostaglandins elevate body temperature and make nerve endings more sensitive to pain transmission). Nabumetone belongs to a group of medicines known as NSAIDs (nonsteroidal anti-inflammatory drugs). 2. Upsides
How do you take nabumetone?
How to use Nabumetone. To prevent stomach upset, take it with food, milk, or an antacid. Dosage is based on your medical condition and response to treatment. To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time.
What is the active metabolite of nabumetone?
Nabumetone is a nonacidic NSAID that is rapidly metabolized in the liver to a major active metabolite, 6-methoxy-2-naphthyl acetic acid. As found with previous NSAIDs, nabumetone’s active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production…
How often can you take nabumetone for osteoarthritis?
Nabumetone dosing information Usual Adult Dose for Osteoarthritis: Initial dose: 1000 mg orally once a day Maintenance dose: 1500 to 2000 mg orally per day in 1 or 2 divided doses
What is the maximum starting dose of nabumetone?
The maximum starting doses of Nabumetone in patients with moderate or severe renal insufficiency should not exceed 750 mg or 500 mg, respectively once daily.
What is the pH of nabumetone?
It is acidic and has an n-octanol: phosphate buffer partition coefficient of 0.5 at pH 7.4. Pharmacokinetics: After oral administration, approximately 80% of a radiolabeled dose of Nabumetone is found in the urine, indicating that Nabumetone is well absorbed from the gastrointestinal tract.