Table of Contents
What is asparaginase made from?
asparaginase made from a type of bacteria called Escherichia coli (also known by its brand Spectrila)
Who makes Erwinase?
Jazz was the commercial partner to Porton Biopharma Limited (PBL), the owner and manufacturer of Erwinase, a treatment option for acute lymphoblastic leukemia (ALL) patients with a sensitivity to E. coli-derived asparaginase.
How is asparaginase produced?
L-asparaginase is produced from a variety of microbial sources including fungi, yeast, bacteria and actinomycetes by the process of submerged fermentation8. Currently, L-asparaginases derived from two bacterial sources, Erwinia chrysanthemi and E. coli, are in clinical use for the treatment of ALL9.
Where is asparaginase found?
Asparaginase is isolated from Escherichia coli (EC-2 form) and Erwinia chrysanthemi. It contains four identical subunits. Lyophilized asparaginase is a white crystalline powder or plug that is stored under refrigeration. Avoid contact with skin, mucous membranes or eyes, and avoid inhaling the dust or vapor.
Is Erwinase available in the US?
Erwinase is available in the U.S. only by prescription. There is no barcode on this product for use with U.S. barcode scanning systems.
Is asparaginase found in humans?
The human asparaginase enzyme (ASPG) inhibits growth in leukemic cells – PMC. The .
What kind of enzyme is asparaginase?
Asparaginase is a bacterial enzyme that reduces the availability of asparagine, an amino acid that is necessary for the growth of some tumor cells.
Who discovered asparaginase?
Following the seminal discovery by Kidd in 1953,[5] asparaginase has been a mainstay of pediatric chemotherapy protocols to treat patients with ALL.
What is Erwinia chrysanthemi asparaginase?
It is a form of asparaginase made from the bacterium Erwinia chrysanthemi. It is used in patients who can no longer take asparaginase made from E. coli. Asparaginase erwinia chrysanthemi is also being studied in the treatment of other types of cancer.
What is antineoplastic asparaginase?
Antineoplastic agent; enzyme derived from Erwinia chrysanthemi (formerly Erwinia carotovora; also known as Pectobacterium chrysanthemi ). Component of combination chemotherapy for treatment of ALL in patients who are hypersensitive to E. coli -derived asparaginase preparations; designated an orphan drug by FDA for this use.
It is often made from Escherichia coli or Erwinia chrysanthemi. Asparaginases can be used for different industrial and pharmaceutical purposes. E. coli strains are the main source of medical asparaginase.
Does Erwinaze increase asparaginase activity?
The approved regimen of intramuscular Erwinaze® was associated with sustained, clinically meaningful asparaginase activity in patients with ALL who had to discontinue treatment with pegaspargase (a pegylated formulation of E. coli asparaginase) because of hypersensitivity.