What do you mean by hemagglutination inhibition?
The hemagglutination inhibition (HI) assay is used to titrate the antibody response to a viral infection. The HI assay takes advantage of some viruses’ ability to hemagglutinate (bind) red blood cells, therefore forming a “lattice” and preventing the red blood cells from clumping.
What is the HI test?
(hē’mă-glū-ti-nā’shŭn) The agglutination of red blood cells; may be immune (as a result of specific antibody to red blood cell antigens or other antigens that coat the red blood cells), or nonimmune (as in hemagglutination caused by viruses or other microbes). Synonym(s): haemagglutination.
What immune protein does a positive hemagglutination test indicate?
Positive control allantoic fluid is known to contain a high infectivity titre of Newcastle disease virus. It should always test positive for the presence of haemagglutinins. Haemagglutination should be visible. This test can determine the presence of a haemagglutinating agent in one minute.
What is meant by hemagglutination?
Hemagglutination is a reaction that causes clumping of red blood cells in presence of some enveloped viruses, such as the influenza virus. A glycoprotein on the viral surface, namely hemagglutinin, interacts with red blood cells, leading to the clumping of red blood cells and the formation of a lattice.
What is hemagglutination in immunology?
What is a hemagglutination inhibition test used for?
The hemagglutination inhibition (HI) assay for influenza A virus has been used since the 1940s. The assay may be utilized to detect or quantify antibodies to influenza A viruses and can be used to characterize differences in antigenic reactivity between influenza isolates.
What is the principle of hemagglutination?
The principle behind the hemagglutination test is that the nucleic acids of viruses encode proteins, such as hemagglutinin, that are expressed on the surface of the virus (Figs.
What does hemagglutinin mean?
hemagglutinin, any of a group of naturally occurring glycoproteins that cause red blood cells (erythrocytes) to agglutinate, or clump together. These substances are found in plants, invertebrates, and certain microorganisms.
What is another term for agglutination?
What is another word for agglutination?
| accretion | adhesion |
|---|---|
| clumping | cohesion |
| joining |
What is the role of hemagglutinin?
The hemagglutinin(HA) of influenza virus is a major glycoprotein and plays a crucial role in the early stage of virus infection: HA is responsible for binding of the virus to cell surface receptors, and it mediates liberation of the viral genome into the cytoplasm through membrane fusion.
Is hemagglutinin a virulence factor?
Molecules known as virulence factors are produced by bacteria, viruses, and fungi to help them to infect host cells. One of virulence factors found in the influenza A viruses is hemagglutinin (HA).
What is blood agglutination?
The process in which free red blood cells are bound together by an antibody and reduced to a visible pellet when centrifuged, most typically in test tubes.
How do you use the word Agglutinate in a sentence?
A definite agglutination of the suspension was read as a positive reaction. They did not show any agglutination against any of the other 22 group-specific antisera tested.
What is the meaning of hemagglutinin?
What is hemagglutination reaction?
What is another term for agglutinate?
conglomerate, gather, mass, pile (up), stack (up)