Table of Contents
What is non infectious osteomyelitis?
Chronic Non-Infectious Osteomyelitis (CNO) is a chronic, relapsing, self-limiting inflammation of the bone. Although it is rare, CNO has been associated with inflammatory bowel disease and frequently precedes the initial diagnosis.
What causes multifocal osteomyelitis?
What Causes it? CRMO is an auto-inflammatory disorder, meaning the immune system attacks the bones causing inflammation, even though there is no infection. A small fraction of people with CRMO have a genetic component. Some families have more than one person with CRMO.
What is chronic nonbacterial osteomyelitis?
Chronic nonbacterial osteomyelitis (CNO)/chronic recurrent multifocal osteomyelitis (CRMO) is a chronic, sterile, inflammatory disorder in children that primarily affects the bones and can cause bone destruction if untreated [1-4].
What is chronic recurrent multifocal osteomyelitis?
CRMO—also called chronic nonbacterial osteomyelitis (CNO)—is a rare disorder that causes inflammation of the bone. CRMO is an autoimmune disease, in which the immune system mistakenly attacks healthy tissue and organs, causing inflammation.
Does chronic osteomyelitis ever go away?
Although once considered incurable, osteomyelitis can now be successfully treated. Most people need surgery to remove areas of the bone that have died.
Can osteomyelitis cause bone pain?
You may have a fever and then develop pain in the infected area days later. Chronic: Chronic osteomyelitis is a bone infection that doesn’t go away with treatments. It causes bone pain and recurring drainage (pus).
What does multifocal osteomyelitis mean?
Chronic recurrent multifocal osteomyelitis (CRMO) is a disease that causes pain and damage in bones due to inflammation. CRMO is a severe form of chronic nonbacterial osteomyelitis (CNO). It may affect 1 or more bones. Symptoms may come and go for years.
Does CRMO ever go away?
CRMO is a chronic condition where symptoms can come and go for years. Children might have inflammation in other bones of the body without symptoms. For this reason your doctor will want to see your child even if he/she is feeling well.
What causes CRMO flare ups?
Although exact cause of CRMO is unknown, theories include inflammatory disorder, genetic disorder, autoimmune disorder, juvenile seronegative spondyloarthropathy (SNSA) or a low virulence infectious organism. CRMO is most commonly found in the metaphysis of long bones of the lower extremity in children and adolescents.
How many cases of CRMO are there in the world?
According to the Eurofever registry [4], there are only slightly more then 460 cases registered world-wide so far, with a prevalence of 1–9/million. [5]. As CRMO is the diagnosis of exclusion and can imitate other inflammatory bone conditions, it is thought to be underestimated [6].