Table of Contents
What does miR 200 do?
The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2.
How can micrornas miRnas regulate gene expression?
How microRNA controls gene expression. microRNA controls gene expression mainly by binding with messenger RNA (mRNA) in the cell cytoplasm. Instead of being translated quickly into a protein, the marked mRNA will be either destroyed and its components recycled, or it will be preserved and translated later.
How are miRNAs named?
Unlike the descriptive names that genes have, miRNAs are simply named sequentially. For example, if the last published novel human miRNA was hsa-miR-400, then next published will be named hsa-miR-401.
Where is MicroRNA found?
While the majority of miRNAs are located within the cell, some miRNAs, commonly known as circulating miRNAs or extracellular miRNAs, have also been found in extracellular environment, including various biological fluids and cell culture media.
What is microRNA and its function?
MicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form mature microRNA.
What is the miR-200 family of microRNAs?
In this review, we discuss the miR-200 family, which is composed of five members (miR-141, miR-200a/200b/200c and mi … In the last decade, microRNAs (miRs or miRNAs) became of great interest in cancer research due to their multifunctional and active regulation in a variety of vital cellular processes.
What is the function of microRNAs in epithelial-mesenchymal transition?
MicroRNAs (miRNAs) are reported to function as a major component in the cellular signaling circuit, which regulates epithelial-mesenchymal transition (EMT). Dysregulation of the microRNA-200 (miR-200) family and EMT-associated genes enables tumor metastasis and resistance to therapy.
What does miR-200 stand for?
Dysregulation of the microRNA-200 (miR-200) family and EMT-associated genes enables tumor metastasis and resistance to therapy.
Is there a real-time PCR assay for microRNAs using s-poly?
Kang K, Zhang X, Liu H, Wang Z, Zhong J, Huang Z, Peng X, Zeng Y, Wang Y, Yang Y, et al. A novel real-time PCR assay of microRNAs using S-Poly (T), a specific oligo (dT) reverse transcription primer with excellent sensitivity and specificity. PLoS One. 2012; 7 :e48536. doi: 10.1371/journal.pone.0048536.