What is allogeneic Pbsct?
Abstract. Allogenic peripheral blood stem cells (PBSC) were used for graft failure after BMT in two patients. These PBSC were mobilized by G-CSF in the same donors, harvested and given without reconditioning to the patients.
What does Pbsct stand for?
Blood-Forming Stem Cell Transplants.
What is allogeneic hematopoietic?
An allogeneic hematopoietic cell transplant uses a donor’s bone marrow or blood. The donor is usually a relative of the patient, although unrelated donors or umbilical cord blood are sometimes used.
How is Pbsct done?
(Step 1): Blood is taken from a vein in the arm of the donor. The patient or another person may be the donor. The blood flows through a machine that removes the stem cells. Then the blood is returned to the donor through a vein in the other arm.
What is allogeneic hematopoietic stem cell?
An allogeneic stem cell transplant uses healthy blood stem cells from a donor to replace bone marrow that’s not producing enough healthy blood cells. An allogeneic stem cell transplant is also called an allogeneic bone marrow transplant. A donor may be a family member, an acquaintance or someone you don’t know.
What are the side effects of bone marrow transplant?
Stem Cell or Bone Marrow Transplant Side Effects
- Mouth and throat pain.
- Nausea and vomiting.
- Infection.
- Bleeding and transfusions.
- Interstitial pneumonitis and other lung problems.
- Graft-versus-host disease.
- Hepatic veno-occlusive disease (VOD)
- Graft failure.
What are the risks of donating stem cells?
The injection that increases the number of stem cells in the blood can cause side effects, such as bone pain, muscle aches, headache, fatigue, nausea and vomiting. Other possible side effects include being lightheaded or having chills, numbness or tingling around the mouth, and cramping in the hands.
What is the difference between syngeneic and allogeneic stem cell transplants?
In syngeneic transplants, patients receive stem cells from their identical twin. In allogeneic transplants, patients receive stem cells from their brother, sister, or parent. A person who is not related to the patient (an unrelated donor) also may be used.
Where does PBSCT stem cells come from?
The stem cells used in PBSCT come from the bloodstream. A process called apheresis or leukapheresis is used to obtain PBSCs for transplantation. For 4 or 5 days before apheresis, the donor may be given a medication to increase the number of stem cells released into the bloodstream.
What are the sources of allogeneic stem cell transplantation?
Stem cell sources: Peripheral blood stem cells and bone marrow for allogeneic transplantation. In: Soiffer RJ, editor. Stem Cell Transplantation for Hematologic Disorders. Humana Press; 2004. pp. 337–356. [Google Scholar] 26.
What is the prognosis of allogeneic PBSCT?
Overall, allogeneic PBSCT was associated with a statistically significant improvement in disease-free survival over BMT (OR = 0.80; 95% CI, 0.67 to 0.97; P= .02; 59% v53% at 3 years and 54% v47% at 5 years, respectively; Fig 8).