What is EGFR exon 18 mutation?
EGFR exon 18 mutations are listed as uncommon mutations involving missense and deletion/insertion mutations. However, patients with EGFR exon 18 mutations have heterogeneous outcomes after taking different EGFR-TKIs (9, 19, 21).
How many NSCLC have EGFR mutation?
NSCLC accounts for around 80–85% of all lung cancers. Research from 2020 estimates that 32.4% of NSCLC cases have the EGFR mutation. On the other hand, EGFR mutations in SCLC are rare.
What is sensitizing EGFR mutation?
Epidermal growth factor receptor (EGFR) is one of the mutated proto-oncogenes in lung adenocarcinoma, where a sensitizing EGFR mutation can result in constitutive activation of tyrosine kinase (TK) and phosphorylation of downstream pathways leading to uncontrolled proliferation, invasion and metastasis.
What is the g719x mutation in EGFR?
The G719X mutation in EGFR refers to point mutations that result in substitutions of the glycine at position 719 to other residues, primarily alanine (G719A), cysteine (G719C) and serine (G719S). The G719X mutation accounts for approximately 3% among all EGFR mutations in both Asian and Caucasian populations (14–22) (Fig. 1).
What is EGFR g719s for non-squamous non-small cell lung carcinoma?
EGFR G719S is an inclusion criterion in 1 clinical trial for non-squamous non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains EGFR G719S and non-squamous non-small cell lung carcinoma as inclusion criteria, 1 is phase 3 (1 open) [ 5 ].
What is the difference between g719x and complex mutations?
Compared with the G719X single mutation, complex mutations are scarcer and their sensitivities to TKI are more obscure. Our research model provides practical approaches for studying these complex mutations. Second generation EGFR-TKIs and G719X
Can TKI treatment reverse the effects of the g719s mutation?
If TKI treatment could reverse the impairment of negative regulation by the G719S mutation, this could be another explanation of the sensitivity to TKIs. However, we found no studies regarding the internalization or recycling of G719S mutated EGFR.