What is the difference between strontium citrate and strontium ranelate?
They are both strontium salts. Strontium ranelate is composed of two atoms of stable strontium (natural) and a molecule of ranelic acid (synthetic/man-made). Strontium citrate is composed of two atoms of strontium and a molecule of citric acid.
Why was strontium ranelate discontinued?
Servier, who manufactured the drug at the time, said the decision to cease marketing and supply was based on commercial reasons. This followed safety concerns about the drug being connected to cardiovascular risks, which had led to its limited use and a continuous decline in the number of people being treated with it.
How much strontium citrate should I take for osteoporosis?
Dosing. BY MOUTH: For weak and brittle bones (osteoporosis): 0.5-2 grams of strontium ranelate has been taken daily for up to 10 years. The highest dose of 2 grams daily seems to work the best.
Is it safe to take strontium citrate?
For strontium ranelate, the blood clot effects were measured within the first year of use. In the two recent studies using strontium citrate for one year, there were no adverse effects of any kind either self-reported or from blood samples.
Is strontium citrate safer than strontium ranelate?
Strontium ranelate has never been approved in the U.S. The forms of strontium available over-the-counter in the U.S. or on the Internet are usually strontium citrate or strontium chloride. These forms are different from the ranelate compound and there have been no studies showing that they are safe or effective.
What are the effects of strontium ranelate?
Common adverse effects of strontium ranelate include headache, nausea and diarrhoea. Although the incidence is less than 1%, there is a higher risk of venous thromboembolism in patients taking strontium ranelate.
Is strontium ranelate still available?
The manufacturer of strontium ranelate (Protelos®) communicated the intention to cease supply of this medicines in May 2017. In that notification it was advised that production and distribution would cease at the end of August 2017.
Is strontium ranelate available in the US?
Does strontium citrate increase bone density?
Over-the-counter supplements containing strontium citrate are available in the US, which is being widely self-administered by patients to improve bone density. SrR has been shown in vivo and in vitro studies to simultaneously decrease bone resorption and increase bone formation [7, 8].
Does strontium citrate help osteoporosis?
It is FDA-approved for the prevention and treatment of osteoporosis in postmenopausal women and to reduce risk of invasive breast cancer in postmenopausal women at high risk or with osteoporosis. SERMs were developed to reap the benefits of estrogen while avoiding the hormone’s potential side effects.
When is the best time to take strontium citrate?
Strontium comes in 2 gram sachets. The dose is one sachet every day. It should be taken on an empty stomach at least two hours after eating. The best time to take it is at night before going to bed.
How do you take strontium ranelate?
Take strontium ranelate separated from calcium-containing food and supplements. Take on an empty stomach. Take strontium ranelate between meals and at least 2 hours after eating at bedtime for optimal bioavailability.
What is strontium citrate?
What foods contain strontium citrate?
In your diet, you get it mainly from seafood, but you can also get small amounts of it in whole milk, wheat bran, meat, poultry, and root vegetables.
Is strontium ranelate effective?
Overall, the clinical data available suggest that strontium ranelate is an effective and generally well tolerated option for the first-line treatment of postmenopausal osteoporosis.
When should strontium ranelate be taken?
Strontium ranelate aims to overcome the problems associated with strontium. Patients take 2 g of granules in water. As the slow absorption is reduced by food, the dose should be taken at bedtime at least two hours after eating. Binding in the gut can reduce the absorption of some antibiotics.