Table of Contents
What is the pathogenesis of Plasmodium falciparum?
The pathogenesis of human P falciparum infection is a complex interplay of parasite-induced RBC alterations2 and microcirculatory abnormalities,12 accompanied by local and systemic immune reactions, resulting in multiple clinical forms of variable severity.
What is the pathogenesis of malaria parasite?
PATHOGENESIS. Severe malaria is predominantly caused by Plasmodium falciparum because of its ability to induce infected red blood cell (RBC) cytoadherence to the vascular endothelium and consequent end-organ dysfunction.
How does Plasmodium falciparum cause malaria?
Plasmodium falciparum is a unicellular protozoan parasite of humans, and the deadliest species of Plasmodium that causes malaria in humans. The parasite is transmitted through the bite of a female Anopheles mosquito and causes the disease’s most dangerous form, falciparum malaria.
What is the lifecycle of Plasmodium falciparum?
[A] Human liver stages (exo-erythrocytic cycle ) (1) The female anopheles mosquito injects parasites (sporozoites) into the human after a blood meal. Sporozoites travel into the bloodstream to the liver. (2) Sporozoites invade the liver cells (hepatocytes). (3) Sporozoites mature into schizonts.
Why is Plasmodium falciparum the most virulent malaria parasite?
Abstract. Plasmodium falciparum is the most deadly of the human malaria parasites. The particular virulence of this species derives from its ability to subvert the physiology of its host during the blood stages of its development.
Which type of malaria is caused by Plasmodium falciparum?
How does malaria affect the placenta?
Recent Findings. Placental malaria, characterized by the accumulation of Plasmodium-infected red blood cells in the placental intervillous space, leads to adverse perinatal outcomes such as stillbirth, low birth weight, preterm birth, and small-for-gestational-age neonates.
Can malaria be transmitted through placenta?
Malaria during pregnancy may result in fetal exposure to malaria if parasites are transmitted across the placenta and could result in congenital malaria.
What is schizogony and sporogony?
Sporogony is an asexual stage of spore formation in parasites. Schizogony is the multiplicative stage of the parasites. Mechanism. The oocyte divides mitotically to produce infectious sporozoites. The sporozoites divide rapidly to produce merozoites.