Table of Contents
What does kinase C include?
Protein kinase C (PKC) is a key family of enzymes involved in signalling pathways that specifically phosphorylates substrates at serine/threonine residues, influencing a variety of cellular events such as cell proliferation and the regulation of gene expression.1, 2 PKC is a subfamily of AGC (PKA, PKG and PKC) kinases.
What does protein kinase C do in smooth muscle?
Protein kinase C was first implicated in the regulation of smooth muscle contraction with the observation that phorbol esters induce slowly developing, sustained contractions.
What causes muscle fatigue?
Muscle weakness is commonly due to lack of exercise, ageing, muscle injury or pregnancy. It can also occur with long-term conditions such as diabetes or heart disease. There are many other possible causes, which include stroke, multiple sclerosis, depression, fibromyalgia and chronic fatigue syndrome (ME).
What is the function of protein kinase C?
Protein kinase C. Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
How are protein kinase C enzymes transported to the plasma membrane?
Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins (membrane-bound receptor for activated protein kinase C proteins).
What is the consensus sequence of protein kinase C enzymes?
The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A, since it contains basic amino acids close to the Ser/Thr to be phosphorylated.
How do protein kinase C kinases affect T cell activation?
A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about 30 years. However, despite the wealth of information on PKC-mediated control of, T cell activation, understanding of the effects of PKCs on the cell cycle machinery in this cell type remains limited.