Table of Contents
What drugs are imidazoles?
Many imidazole-based derivatives have been marketed as antifungal drugs such as ketoconazole (1), miconazole (2), clotrimazole (3), tioconazole (4), econazole (5), tinidazole (6), enilconazole/imazalil (7), parconazole (8), eberconazole (9), lanoconazole (10), fenticonazole (11), bifonazole (12), sulconazole (13).
What are imidazoles used for?
The imidazoles are used to treat systemic fungal diseases, dermatophyte infections that have not responded to griseofulvin or topical therapy, Malassezia infection in dogs, aspergillosis, and sporotrichosis in animals that cannot tolerate or do not respond to sodium iodide.
How do you synthesis imidazole?
A ketone oxidation, employing catalytic HBr and DMSO, followed by imidazole condensation with aldehydes provides 2,4(5)-disubstituted imidazoles in good yields. A three-step synthesis of 20 kinase inhibitors was achieved by employing this oxidation-condensation protocol, followed by bromination and Suzuki coupling.
Are imidazoles aromatic?
Imidazole is an important aromatic ring found in many proteins. It has two nitrogen atoms. One resembles pyrrole and is not basic. The second nitrogen is structurally similar to the nitrogen atom of pyridine.
Which antibiotics treat fungal infections?
Common names for antifungal medicines include:
- clotrimazole (Canesten)
- econazole.
- miconazole.
- terbinafine (Lamisil)
- fluconazole (Diflucan)
- ketoconazole (Daktarin)
- nystatin (Nystan)
- amphotericin.
What is structure of imidazole?
C3H4N2Imidazole / Formula
What is the difference between imidazoles and triazoles?
The key difference between imidazole and triazole is that imidazole has non-adjacent nitrogen atoms in its chemical structure whereas triazole has adjacent nitrogen atoms in its chemical structure. Both these compounds are important medicines and have many other applications as well.
Which antifungal is best?
The most widely used are terbinafine for nail infections, miconazole, and nystatin for oral thrush, and fluconazole for vaginal thrush. These usually cause no side-effects. You can even buy fluconazole without a prescription at pharmacies, as it is considered a medicine which is unlikely to cause problems.
How do you pronounce triazoles?
- Phonetic spelling of triazole. tri-a-zole. trahy-uh-zohl.
- Meanings for triazole.
- Synonyms for triazole. triazolo.
- Translations of triazole. Indonesian : triazol. Japanese : トリアゾール Chinese : 三唑 Arabic : الترايازول Spanish : triazol. Show more Translation.
How do you spell griseofulvin?
Phonetic spelling of griseofulvin
- grise-o-ful-vin.
- GRIS-ee-oh-FUL-vin.
- griz-ee-oh-foo l-vin.
What is imidazole?
Imidazole is nitrogen-containing heterocyclic ring which possesses biological and pharmaceutical importance. Thus, imidazole compounds have been an interesting source for researchers for more than a century.
How effective are imidazoles against Trypanosoma?
Additionally, the in vivo study revealed that the imidazoles exhibited promising anti-Trypanosoma efficacy corroborating the in vitro anti-parasite capacity. In particular, three imidazole compounds (C1, C6, and C8) not only cleared the systemic parasite burden but cured infected rats after no death was recorded.
Are imidazole-derived compounds an alternative anti-Trypanosoma agent?
In this regard, imidazole-derived compounds hold prospects for development as alternative anti-Trypanosoma agents. For decades, compounds with imidazole nucleus have been used to treat parasitic diseases.
What is imidazole scaffold?
Imidazole scaffold is a ubiquitous motif that is present in several pharmacologically important drug molecules such as Metronidazole, Pretomanid, Ketoconazole, Tipifarnib, Megazole, Nafimidone, Losartan, etc. They have been widely explored by the scientific community and are reported to possess a broad spectrum of biological activities.