Table of Contents
What is pegloticase used for?
Pegloticase injection is used to treat chronic gout in adult patients who have already been treated with other medicines that did not work well. Gout is a condition that is caused by too much uric acid in the blood (hyperuricemia). Pegloticase injection works by causing less uric acid to be produced by the body.
What is the mechanism of action of pegloticase?
Pegloticase is a pegylated, recombinant uricase (urate-oxidase), created by a genetically altered variant of Escherichia coli that exerts its mechanism of action by catalyzing uric acid to the water-soluble purine metabolite allantoin.
What type of drug is pegloticase?
Pegloticase injection is in a class of medications called PEGylated uric acid specific enzymes. It works by decreasing the amount of uric acid in the body. Pegloticase injection is used to prevent gout attacks but not to treat them once they occur.
Can you take pegloticase with allopurinol?
allopurinol pegloticase Using pegloticase together with allopurinol is not recommended. Treatment with pegloticase requires monitoring of uric acid levels in the blood to reduce the risk of side effects such as allergic and infusion reactions, and allopurinol can interfere with the monitoring.
What is colchicine side effects?
Side Effects
- Black, tarry stools.
- blood in the urine or stools.
- burning, “crawling”, or tingling feeling in the skin.
- difficulty with breathing when exercising.
- fever with or without chills.
- large, hive-like swellings on the face, eyelids, mouth, lips, or tongue.
- muscle weakness.
- numbness in the fingers or toes (usually mild)
What is a common side effect for allopurinol?
Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
What is Pegloticase used to treat?
Pegloticase (trade name Krystexxa) is a medication for the treatment of severe, treatment-refractory, chronic gout. It is a third line treatment in those in whom other treatments are not tolerated. The drug is administered by infusion intravenously .
What is the generic name for Pegloticase?
Pegloticase. Pegloticase (trade name Krystexxa) is a medication for the treatment of severe, treatment-refractory, chronic gout. It is a third line treatment in those in whom other treatments are not tolerated. The drug is administered by infusion intravenously . It was developed by Savient Pharmaceuticals.
What is Krystexxa (Pegloticase)?
Pegloticase (trade name Krystexxa) is a medication for the treatment of severe, treatment-refractory, chronic gout.
Is Pegloticase effective in the treatment of chronic gout?
Pegloticase (Krystexxa, Horizon Pharma; Dublin, Ireland), a recombinant pegylated uricase, was approved by the US Food and Drug Administration (FDA) in 2010 for chronic gout in adult patients refractory to conventional therapy (www.accessdata.fda.gov). In this manuscript, we review the efficacy and safety profile of pegloticase. The burden of gout