Table of Contents
What are methods of therapeutic drug monitoring?
The most commonly used procedures are fluorescence polarization immunoassay (FPIA), enzyme immunoassay (EMIT), and enzyme-linked immunosorbant assay (ELISA) [31,32]. These assays are specific; however, in certain cases, metabolites or other drug-like substances are also recognized by the experimental antibody [33-35].
What is required for therapeutic drug monitoring?
Therapeutic drug monitoring involves not only measuring drug concentrations, but also the clinical interpretation of the result. This requires knowledge of the pharmacokinetics, sampling time, drug history and the patient’s clinical condition.
What is the best specimen for drug monitoring?
Which specimens are appropriate for therapeutic drug monitoring? Whole blood, serum, and plasma specimens can be used to assess whether the drug dosage achieved the targeted therapeutic range and to evaluate patient adherence.
What is TDM level?
Therapeutic drug monitoring (TDM) is testing that measures the amount of certain medicines in your blood. It is done to make sure the amount of medicine you are taking is both safe and effective. Most medicines can be dosed correctly without special testing.
What is the best specimen for drug monitoring serum or urine?
Serum is the preferred specimen for therapeutic drug monitoring, because drug concentrations in the specimen reflect the drug’s disposition at collection time. When the time and amount of the previous dose are known, the measurement can be compared with a predicted blood concentration of the drug.
Which drug is not needed to be TDM?
The effectiveness of these treatments has been evaluated, but monitoring the concentration of the drug in the blood is not required for dosing. Examples of drugs that do not require monitoring include high blood pressure (hypertension) medications and many of the antibiotics given to treat bacterial infections.
When is therapeutic drug monitoring done?
Once a person’s results are in the therapeutic range and his or her clinical signs indicate that the treatment is appropriate, then the healthcare professional may monitor the drug at less frequent intervals as needed to ensure that the drug concentration stays in the therapeutic range.
What is the purpose of a PK study?
A pharmacokinetic (PK) study of a new drug involves taking several blood samples over a period of time from study participants to determine how the body handles the substance. These studies provide critical information about new drugs.
What is peak drug level?
The peak level is the highest concentration of a drug in the patient’s bloodstream. Note: Random drug levels may be ordered and are appropriate for monitoring drug usage if drug is being administered by continuous IV infusion.