Why Trifluoromethylation is important?
Trifluoromethylation reactions have attracted a great deal of attention in recent years, as this methodology provides access to several fluorinated compounds which have great importance in medicinal chemistry. 5-(Trifluoromethyl)uracil and -uridine derivatives also have shown strong antitumor and antiviral activities.
Is trifluoromethyl hydrophobic?
Trifluorination strongly enhances lipophilicity only when the trifluoromethyl group is in the alpha-position. The enhancement is barely measurable for the beta- and gamma-(trifluoromethyl) alcohols, while the delta- and epsilon-(trifluoromethyl) compounds are considerably more hydrophilic than their parent compounds.
Is trifluoromethyl a good leaving group?
The trifluoromethyl (-CF3) group is one of the most powerful electron withdrawing groups in structural organic chemistry. This property is often manifested by increasing reactivities of adjacent acidic or electrophilic functional groups.
How do you introduce trifluoromethyl group?
Trifluoromethanesulfonyl chloride. Trifluoromethanesulfonyl chloride (or triflyl chloride, CF3SO2Cl) can be used in a highly efficient method to introduce a trifluoromethyl group to aromatic and heteroaromatic systems, including known pharmaceuticals such as Lipitor.
Where can I work as medicinal chemist?
Medicinal chemists work in biological laboratories for pharmaceutical companies, biotech firms, government agencies, universities or research institutes. They are vital to the drug industry and the medical field. In the lab, teams are comprised of multiple scientists of different backgrounds.
Is trifluoromethyl electron donating?
Is trifluoromethyl polar or nonpolar?
Nonpolar
4.1 Nonpolar trifluoromethyl-substituted α-amino acids.
What can I do with a degree in medicinal chemistry?
Medicinal chemists research and develop chemical compounds that can be used as pharmaceutical drugs. They work on teams with other scientists and engineers to create and test new drug products. They also help develop new and improved manufacturing processes to effectively produce new drugs on a large scale.
What degree is a medicinal chemist?
Minimum qualifications needed for role: Most medicinal chemists hold a PhD in chemistry (usually in the field of synthetic organic chemistry, or with a substantial organic chemistry component) but there are also opportunities or junior positions for those with a master’s degree in chemistry.