Table of Contents
What is ttf1 positive?
TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2]. This explains why this marker is frequently used to search for the primary origin of metastatic neuroendocrine tumours.
What is combined small cell carcinoma?
Combined small-cell lung carcinoma (C-SCLC) is defined by the World Health Organization (WHO) as small-cell carcinoma (SCLC) combined with additional components that consist of any of the histological types of non-small-cell lung carcinoma (NSCLC); usually adenocarcinoma (ADC), squamous-cell carcinoma (SCC), large-cell …
Can small cell carcinoma spread?
Small cell lung cancer that spreads is treatable but generally isn’t curable. Other complications include: Pleural effusion (fluid buildup in the area outside of the lungs). Cancer recurrence (return) after treatment, often in the central nervous system (brain or spine) or chest.
Why is it called small cell carcinoma?
The cancer cells of each type grow and spread in different ways. The types of small cell lung cancer are named for the kinds of cells found in the cancer and how the cells look when viewed under a microscope: Small cell carcinoma (oat cell cancer).
What is TTF-1 a marker for?
Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas.
Can small cell carcinoma be cured?
Although small cell lung cancer is an aggressive disease, it responds well to initial chemotherapy and radiation. The goal of treatment for people with limited-stage small cell lung cancer is cure, which is achieved in 20 to 25 percent of patients.
Can you survive small cell carcinoma?
The general 5-year survival rate for people with SCLC is 7%. It is important to note that survival rates depend on several factors, including the stage of disease. For people with localized SCLC, which means the cancer has not spread outside of the lung, the overall 5-year survival rate is 27%.
How long can you live with small cell carcinoma?