Table of Contents
What are the side effects of pentamidine?
Side Effects
- Burning pain, dryness, or sensation of lump in throat.
- chest pain or congestion.
- coughing.
- difficulty in breathing.
- difficulty in swallowing.
- skin rash.
- wheezing.
How to give pentamidine injection?
Pentamidine injection comes as powder to be mixed with liquid to be injected intramuscularly (into a muscle) or intravenously (into a vein) by a doctor or nurse in a medical facility. If it is given intravenously, then it is usually given as a slow infusion over 60 to 120 minutes.
How to dilute pentamidine?
The contents of one vial (300 mg) should first be dissolved in 3 to 5 mL of Sterile Water for Injection, USP, or 5% Dextrose Injection, USP at 22°- 30°C (72° – 86°F). The calculated dose of pentamidine isethionate should then be withdrawn and diluted further in 50 to 250 mL of 5% Dextrose Injection, USP.
Is pentamidine a chemo drug?
Pentamidine is an antibiotic used for pneumonia treatment. Drugs used in chemotherapy, such as ifosfamide, carboplatin and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Why is pentamidine hazardous?
Aerosolized pentamidine also has been shown to be embryotoxic in animals. Respiratory irritation, shortness of breath, ocular irritation, asthma, and skin rash have been reported by health-care workers administering aerosolized ribavirin.
What is pentamidine injection used for?
Pentamidine is used to treat Pneumocystis carinii pneumonia (PCP), a very serious kind of pneumonia. This kind of pneumonia occurs commonly in patients whose immune system is not working normally, such as cancer patients, transplant patients, and patients with acquired immune deficiency syndrome (AIDS).
Does pentamidine increase blood pressure?
Pentamidine may cause some serious side effects, including heart problems, low blood pressure, low or high blood sugar, and other blood problems.
Is pentamidine a hazardous drug?
Respiratory care practitioners administer aerosolized drugs, such as pentamidine and various antibiotics, to treat respiratory infections. At the time of the survey, pentamidine was classified by NIOSH as a hazardous drug with rigorous safe handling guidelines.
Is pentamidine toxic?
Pentamidine is quite toxic. Approximately 50% of patients taking the drug at recommended doses will show some adverse effect. Frequent adverse effects include pain and swelling at the injection site, hypotension, vomiting, blood dyscrasias, and renal damage.
How often is pentamidine given?
Adults and children 5 years of age and older—300 milligrams (mg) by oral inhalation once every four weeks. Children younger than 5 years of age—Use and dose must be determined by your doctor.
Is pentamidine an antibiotic?
Pentamidine, however, is not a traditional antibiotic. The drug is widely used in the treatment of parasitic and fungal infections, but not as an agent for the treatment of common bacterial infections.
How often do you take pentamidine?
How should this medicine be used? Pentamidine comes as a solution to be inhaled using a nebulizer. It usually is used once every 4 weeks. Inhalation of pentamidine delivers the drug directly to your lungs.
What is the use of pentacarinat?
Pentacarinat is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. For the treatment of pneumonia due to Pneumocystis carinii.
How many mg of pentacarinat is in a vial?
These measures will help to protect the environment. Each small glass bottle (vial) contains 300mg the active substance, Pentamidine isetionate (equivalent to 172.4 mg pentamidine base). Pentacarinat powder is a white or almost white plug of lyophilised powder contained in a glass vial.
Is pentacarinat safe to take for pneumonia?
It is generally well-tolerated. Pentacarinat is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. For the treatment of pneumonia due to Pneumocystis carinii. Pentacarinat is also used to associated treatment for these conditions: Pneumocystis Jirovecii Pneumonia, Trypanosomiasis
How often should pentacarinat be given?
The usual dose of pentacarinat powder for adults, children and infants for the following illnesses is: 4 mg for each kg of body weight, once each day for 14 days. If you have kidney problems, your doctor may give you this medicine less often. The dose is given by a slow infusion (drip) into a vein.