Table of Contents
What is the synthesis of bradykinin?
Bradykinin is formed by the interaction of factor XII, prekallikrein, and high-molecular-weight kininogen on negatively charged inorganic surfaces (silicates, urate, and pyrophosphate) or macromolecular organic surfaces (heparin, other mucopolysaccharides, and sulfatides) or on assembly along the surface of cells.
What is kallikrein activation?
Kallikrein (PKa), generated by activation of its precursor prekallikrein (PK), plays a role in the contact activation phase of coagulation and functions in the kallikrein-kinin system to generate bradykinin.
How do you inhibit bradykinin?
Production of bradykinin can be inhibited by ecallantide, which acts on kallikrein, or by C1-INH, which acts to inhibit formation of kallikrein and HMW kininogen. Activation of the bradykinin β2 receptor is inhibited by icatibant.
What is bradykinin system?
Bradykinin is a potent endothelium-dependent vasodilator and mild diuretic, which may cause a lowering of the blood pressure. It also causes contraction of non-vascular smooth muscle in the bronchus and gut, increases vascular permeability and is also involved in the mechanism of pain.
How is bradykinin metabolized?
Bradykinin is a vasoactive nonapeptide, and is very effectively removed during passage through the lung and other vascular beds. The half-life in blood is about 17 s but less than 4 s in various vascular beds. Like angiotensin I, ACE is the enzyme responsible for metabolism of bradykinin.
Is the important enzyme for the inactivation of bradykinin?
Angiotensin-converting enzyme (ACE) is an enzyme that breaks down and inactivates bradykinin.
Which medication blocks the breakdown of bradykinin?
ACE inhibitors prevent the breakdown of a natural chemical in the body called bradykinin. Increased levels of bradykinin, which can cause swelling, may contribute to the development of angioedema.
Where is kallikrein synthesized?
Tissue kallikrein is synthesized and secreted by human vascular endothelial cells.
What is the function of the Trypsin domain in kallikrein?
Tissue (glandular) kallikrein (KLK) possesses only a trypsin domain. KLKB1 binds to high molecular weight kininogen (KNG) with high affinity and preferentially releases bradykinin (BK). KLKB1 also digests plasminogen to plasmin and participates in surface-dependent activation of blood coagulation, fibrinolysis, and inflammation.
Is bradykinin a peptide?
?) Bradykinin (Greek brady-, slow; -kinin, kīn (eîn) to move) is a peptide that promotes inflammation.
What is bradykinin receptor B1?
The B 1 receptor (also called bradykinin receptor B1) is expressed only as a result of tissue injury, and is presumed to play a role in chronic pain. This receptor has been also described to play a role in inflammation.
What does bradykinin stand for?
Bradykinin (Greek brady-, slow; -kinin, kīn (eîn) to move) is a peptide that promotes inflammation.