Table of Contents
What is kratom tea good for?
As a recreational drug, the leaves are chewed or drank as a tea to elevate mood (as a euphoriant) and enhance physical endurance. As a medicine, kratom is used for anxiety, cough, depression, diabetes, diarrhea, high blood pressure, pain, to improve sexual performance, and to lessen symptoms of opiate withdrawal.
What are the effects of mitragynine?
Kratom (Mitragyna speciosa) is a tree native to Southeast Asia. The leaves contain a chemical called mitragynine, which works like opioids such as morphine. Kratom has pain-relieving effects like opioid drugs. It also has many of the same serious safety concerns as other opioids.
How strong is mitragynine?
Mitragynine pseudoindoxyl was 3-fold more potent than morphine, and 7-hydroxymitragyinine was 5-fold more potent than morphine. Advantageously, mitragynine pseudoindoxyl caused less tolerance, respiratory depression, and inhibition of gastrointestinal motility than equianalgesic doses of morphine.
How many kratom leaves a day?
A common route of administration is by chewing the fresh leaves at a dosage of normally 10 to 30 leaves per day. Kratom can be ingested as crushed dried leaves by taking powder, drinking as a tea or by smoking the leaves or the extract [71].
Is mitragynine toxic?
The referral toxicology laboratory reported an independently fatal concentration of mitragynine of 2500 ng/mL, based on previously published values from mixed drug toxicity case reports (range of 20-1060 ng/mL).
How strong is 7 mitragynine?
Consistent with previous reports,22,25 it was found that 7-OH was a highly potent analgesic (ED50 = 0.6 mg/kg, s.c.), ∼fivefold more potent than p.o. mitragynine.
What percent of kratom is mitragynine?
The mitragynine congeners account for roughly 85% of the total alkaloid concentration of kratom, and the remaining alkaloids each account for less than one percent of the total alkaloid concentration[5, 21].
What is mitragynine toxicity?
It is reported that the combination of “Kratom” and central nervous system depressants might cause respiratory depression [5] and ingestion of such substances may thus have contributed to death. The toxicity of mitragynine in humans is poorly defined, and no toxic or lethal ranges have been established.
Is 7-hydroxymitragynine an opioid?
It was found that 7-hydroxymitragynine is a novel opioid agonist that is structurally different from the other opioid agonists, and has potent analgesic activity when orally administered.
Can kratom affect your blood pressure?
Poison control centers in the United States received about 1,800 reports involving use of kratom from 2011 through 2017, including reports of death. About half of these exposures resulted in serious negative outcomes such as seizures and high blood pressure.
Does kratom lower serotonin?
When you use kratom, your brain’s reward system gets triggered, and your body starts releasing dopamine and serotonin, making you feel euphoric, which, in turn, offers pain relief. Researchers believe that this rise in serotonin levels after kratom consumption could potentially lead to developing serotonin syndrome.
Is liver damage from kratom reversible?
Patients who present with acute liver injury due to kratom usually recover once it is discontinued. There is no evidence that corticosteroids shorten the course of illness or improve outcomes. Patients should be warned against further use of kratom and multiingredient nutrition supplements that might contain it.