What does Versican consist of?
Versican, along with the other hyalectans, consists of an N-terminal G1 domain, a C-terminal G3 domain, and CS chain binding regions between G1 and G3 (Fig. 1). The G1 domain is composed of an immunoglobular (Ig)-like motif, followed by two proteoglycan tandem repeats that are known as HA-binding repeats (HABR).
What is the major function of Versican?
Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix. Due to its widespread expression in the body, versican is involved in cell adhesion, proliferation and migration.
Is Aggrecan a gag?
Almost 90% of aggrecan mass is comprised of substituted GAG chains which are mostly chondroitin sulfate chains, but also include keratan sulfate chains with N- and O-linked oligosaccharides.
What does Versican plus cover?
Versican Plus DHPPi/L4 is a veterinary vaccine that contains live attenuated (weakened) canine distemper virus, canine adenovirus type 2, canine parvovirus type 2b and canine parainfluenza virus type 2 as well as inactivated (killed) strains of Leptospira bacteria.
Is aggrecan a proteoglycan?
Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
Is aggrecan sulfated?
Aggrecan is the only molecule of the aggregating chondroitin sulfate proteoglycan family to contain this domain.
Is hyaluronic acid a GAG?
Hyaluronic acid (HA) has the simplest structure of all GAGs and does not require additional sulfation of functional groups in the Golgi apparatus as do the other GAGs. Instead, the structure consists of sequentially bound glucuronic acid and N-acetylglucosamine residues.
Is Versican vaccine for kennel cough?
canine parainfluenza virus and canine adenovirus type 2, which cause kennel cough. The vaccine is given to puppies from six weeks of age as an injection under the skin which is repeated three to four weeks later.
What vaccine is compatible with Versican?
Versican Plus is the only vaccine to combine DHPPi + L4 in a single injection, the result of several years of innovative research and development. The leptospirosis components of the vaccine have been designed to meet the challenges of both existing and emerging types.
What is aggrecan and what is its function?
Is aggrecan a glycosaminoglycan?
Aggrecan is a high molecular weight (1×106 < M < 3×106) proteoglycan. It exhibits a bottlebrush structure, in which chondroitin sulfate and keratan sulfate glycosaminoglycan (GAG) chains are attached to an extended protein core. Aggrecan has a molecular mass >2,500 kDa.
Where is aggrecan found?
articular cartilage
Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties.
What are proteoglycans examples?
Examples of proteoglycans are versican (a large chondroitin sulfate proteoglycan), perlecan, neurocan, aggrecan, brevican, fibromodulin, and lumican.
Is aggrecan a gag?
What is aggrecan degradation?
Aggrecan degradation is the hallmark of cartilage degeneration in osteoarthritis (OA), though it is unclear whether a common proteolytic process occurs in all individuals.
Is hyaluronic acid inflammatory?
Although Paik supports the use of HA in general, the dermatologist admits that “smaller HA molecules set inflammation in motion,” referencing the many, many studies that show low molecular weight hyaluronic acid has a pro-inflammatory effect on the skin.
What is aggrecan?
The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage . Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.
Is aggrecan a type 2 collagen?
Along with type-II collagen, aggrecan forms a major structural component of cartilage, particularly articular cartilage . The aggrecan family includes other important members such as versican, also named PG-M, neurocan, brevican and the cell surface HA receptor CD44.
What are the members of the aggrecan family?
The aggrecan family includes other important members such as versican, also named PG-M, neurocan, brevican and the cell surface HA receptor CD44.
What is aggrecan in cartilage?
Aggrecan is a large keratan sulfate/chondroitin sulfate-linked proteoglycan (∼2500 kDa), which is prominent in cartilage, but also present in the brain, aorta, and tendons. Its N-terminal domain binds to hyaluronan, an interaction stabilized by link protein.