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Why is simvastatin contraindicated with amlodipine?
amLODIPine simvastatin Combining these medications may significantly increase the blood levels of simvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue.
Is it OK to take simvastatin with amlodipine?
In summary, the available evidence supports the recommendation that the maximum daily dose of simvastatin should not exceed 20 mg when co-administered with amlodipine or diltiazem: concomitant use of either amlodipine or diltiazem increases the exposure to simvastatin through CYP3A4 interactions.
What cholesterol medication can be taken with amlodipine?
Descriptions. Amlodipine and atorvastatin is a combination of a calcium channel blocker and HMG-CoA reductase inhibitor (statin). Amlodipine is used alone or together with other medicines to treat angina (chest pain) or high blood pressure.
Can you take blood pressure and cholesterol medicine at the same time of day?
Taking daily doses of two blood pressure drugs (fixed dose candesartan and hydrochlorothiazide) along with a cholesterol-lowering drug (low-dose rosuvastatin), proved to be the most effective, cutting first-time strokes by 44 percent among patients at intermediate risk for heart disease.
Which statin does not interact with amlodipine?
➢ Pravastatin, fluvastatin or rosuvastatin do not interact with amlodipine.
Can I take blood pressure and cholesterol medication at the same time of day?
Can simvastatin raise your blood pressure?
Background: Simvastatin has been reported to improve endotheliumdependent vascular relaxation in patients with hypercholesterolemia. The consequent decrease in arterial stiffness might be associated with a decrease in blood pressure (BP).
What is the best statin to take with amlodipine?
Change to an alternative statin ➢ Pravastatin, fluvastatin or rosuvastatin do not interact with amlodipine. ➢ Atorvastatin (20mg or 40mg daily) is an option if a more potent statin is needed. The risk of an interaction with amlodipine is much lower with atorvastatin than simvastatin.
What drugs interact with Norvasc?
Most frequently checked interactions
- aspirin.
- Aspirin Low Strength (aspirin)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- gabapentin.
- hydrochlorothiazide.
- Lasix (furosemide)
- Lipitor (atorvastatin)
What are the contraindications for simvastatin?
Simvastatin: new contraindications, precautions and dosage recommendations. Patients on high dose simvastatin and those taking certain other medicines have an increased risk of developing myopathy (muscle weakness) and, more rarely, rhabdomyolysis 1.
What are the side effects of simvastatin 20 mg?
Max dose is simvastatin 20 mg Adverse Effects Common adverse effects include a headache, myalgia, abdominal pain, constipation, and upper respiratory infections.
What are the side effects of Norvasc?
a light-headed feeling, like you might pass out. Common Norvasc side effects may include: swelling in your ankles and lower part of your legs. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the Max dose of simvastatin?
Max dose is simvastatin 10 mg Amiodarone, amlodipine, ranolazine Max dose is simvastatin 20 mg Adverse Effects Common adverse effects include a headache, myalgia, abdominal pain, constipation, and upper respiratory infections.