What produces osteocalcin?
Osteocalcin is among the most abundant proteins in bone and is produced exclusively by osteoblasts. Initially believed to be an inhibitor of bone mineralization, recent studies suggest a broader role for osteocalcin that extends to the regulation of whole body metabolism, reproduction, and cognition.
Where is osteocalcin found?
bone
Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a small (49-amino-acid) noncollagenous protein hormone found in bone and dentin, first identified as a calcium-binding protein in chick bone.
What is osteocalcin hormone?
Importantly, osteocalcin is secreted solely by osteoblasts but only has minor effects on bone mineralization and density. Instead, it has been reported to control several physiological processes in an endocrine manner, such as glucose homeostasis and exercise capacity, brain development, cognition, and male fertility.
What increases osteocalcin?
Weight loss, exercise, and supplements such as vitamin K can help improve bone health and increase osteocalcin levels.
Why is osteocalcin important?
Osteocalcin Is Required for Optimal Adaptation to Exercise Since osteocalcin has been reported to regulate glucose metabolism, which provides energy to muscles during exercise, it may be involved in the communication between these two tissues.
How can I increase my osteocalcin levels naturally?
How can I produce more osteocalcin?
What is the function of the BGLAP gene?
BGLAP bone gamma-carboxyglutamate protein [ (human)] Summary. This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone.
What does BGLAP stand for?
BGLAP (Bone Gamma-Carboxyglutamate Protein) is a Protein Coding gene. Diseases associated with BGLAP include Osteitis Fibrosa and Renal Osteodystrophy. Among its related pathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Metabolism of proteins.
Is there read-through transcription between BGLAP and PMF1?
Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015] BGLAP (Bone Gamma-Carboxyglutamate Protein) is a Protein Coding gene.
Is the BGP gene a genetic marker for osteoporosis in China?
HindIII RFLP of the BGP gene may be limited as a genetic marker to discern women susceptible to low BMD and thus osteoporosis in Chinese relationship between increase in undercarboxylated osteocalcin levels and low bone mineral density in elderly women with type II diabetes mellitus