Table of Contents
Where are transferrin receptors located?
Transferrin receptors are expressed on the surfaces of all cells in concert with their need for iron. A truncated form of the extracellular domain of the receptor is produced by proteolytic cleavage and is present in the plasma in direct proportion to the total number of receptors expressed in all body tissues.
What is human transferrin receptor?
The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to mediate cellular uptake of iron from a plasma glycoprotein, transferrin.
What is serum transferrin receptor?
Transferrin receptors (TfRs) are the conventional pathway by which cells acquire iron for physiological requirements. Under iron-deficient conditions there is an increased concentration of surface TfR, especially on bone marrow erythroid precursors, as a mechanism to sequester needed iron.
Do all cells have transferrin receptor?
With the exception of highly differentiated cells, transferrin receptors are probably expressed on all cells but their levels vary greatly. Transferrin receptors are highly expressed on immature erythroid cells, placental tissue, and rapidly dividing cells, both normal and malignant.
What does the HFE gene do?
The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells. The HFE protein is also found on some immune system cells. The HFE protein interacts with other proteins on the cell surface to detect the amount of iron in the body.
How does the HFE gene cause hemochromatosis?
These mutations prevent the HFE protein from interacting with transferrin receptor 1 and other proteins. As a result, iron regulation is disrupted, and too much iron is absorbed from the diet. This increase in the absorption of dietary iron leads to the iron overload characteristic of type 1 hemochromatosis.
What is the role of transferrin receptor in post transcriptional regulation?
Post-transcriptional regulation. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis . TfR production in the cell is regulated according to iron levels by iron-responsive element-binding proteins, IRP1 and IRP2.
What is transferrin receptor (Tfr)?
Transferrin receptor ( TfR) is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration.
What is the role of transferrin receptor in iron homeostasis?
Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis .
Does transferrin receptor have glycosylation sites?
Transferrin Receptor contains a number of potential glycosylation sites (SwissProt) which may explain its migration at a higher molecular weight than predicted. ab84036 staining Transferrin receptor protein 1 in HeLa cells.