What is CD20 used for?
CD20 has key roles in the differentiation and development of B-cells into plasma cells which could lead to regulation of the proliferation and activation of B cells [2,7]. The increased expression of CD20 has been detected in patients with certain types of B-cell lymphoma and leukemia.
Where is cluster differentiation found?
The cluster of differentiation (CD) designation refers to proteins found on the surface of cells. Each unique surface molecule is assigned a different number, which allows cell phenotypes to be identified. Surface expression of a particular CD molecule is useful for the characterization of cell phenotypes.
What activates CD38?
In the myeloid linage, CD38 expression is induced after activation in inflammatory conditions in both mice and humans. CD38 appears to regulate cytokine release, adhesion, and cellular migration toward sites of inflammation (4, 5, 33, 45, 46).
What is CD38 antibody?
A substance that binds to a protein called CD38, which is found on some types of blood cells and in high levels on some cancer cells, including myeloma cells. Anti-CD38 monoclonal antibody may block the CD38 protein and help the immune system kill cancer cells.
What is CD20 antibody?
Anti-CD20 monoclonal antibodies (mAbs) are used to achieve B cell depletion, and were initially developed to treat B cell proliferative disorders, including non-Hodgkin’s lymphoma (NHL) and chronic lymphocytic leukemia (CLL).
Where is CD20 found?
What Is CD20? CD20 is an antigen that is found on the surface of B cells but not T cells.
What is the importance of the clusters of differentiation protein?
Clusters of Differentiation (CD) markers are widely used for immunophenotyping. In some cases, CD antigens are expressed only at certain stages of development or under certain conditions. Some of the surface antigens are useful for delineating the cell lineage of leukocytes.