What is the chemical makeup of phentermine?
Phentermine | C10H15N – PubChem.
Does phentermine change brain chemistry?
The phentermine/fluoxetine combination also produced greater long-term reductions in brain DA levels than phentermine alone, likely reflecting greater DA neurotoxicity of the drug combination. Brain concentrations of phentermine were also found to be higher in animals pretreated with fluoxetine.
What was phentermine originally used for?
Phentermine was first introduced in 1959 as part of an anti-obesity combination drug. Topiramate was released for commercial use in 1996. Phentermine on its own has been used for short-term treatment of obesity in combination with exercise and caloric restriction.
Is phentermine still on the market?
Fen-Phen was taken off the market by the U.S. Food and Drug Administration (FDA) in 1997 after safety concerns surrounding fenfluramine. Phentermine alone, however, has been used for decades and appears to be a safe and effective weight loss medication when used in the short-term in healthy individuals.
Does phentermine deplete dopamine?
Phentermine is an amphetamine and can lead to dopamine depletion.
Can phentermine cause permanent damage?
Phentermine may increase your thyroid activity. This may raise your thyroid levels even further. For people with glaucoma: This drug may increase your eye pressure even more. This may cause permanent damage to your vision.
Why was fen-phen taken off the market?
The FDA ordered fenfluramine and dexfenfluramine off the market in September 1997 after those drugs were linked to heart valve problems. Fenfluramine was one of the ingredients in “fen-phen,” and dexfenfluramine is closely related to fenfluramine.
Is Topamax the same as phentermine?
Phentermine is in a class of medications called anorectics. It works by decreasing appetite. Topiramate is in a class of medications called anticonvulsants. It works by decreasing appetite and by causing feelings of fullness to last longer after eating.
Does phentermine boost serotonin?
Phentermine is a sympathomimetic amine that works on the central nervous system to suppress appetite. It has been shown to stimulate the release of norepinephrine in the hypothalamus, with no effects on serotonin.
Is phentermine hard on your kidneys?
This medicine may increase the chance of developing metabolic acidosis. If left untreated, this can cause kidney stones, bone disease, or slowed growth in children. Symptoms include breathing fast, fatigue, loss of appetite, irregular heartbeat, or loss of consciousness.
Which is better for weight loss phentermine or Topamax?
The mean weight loss achieved for the maximum dose combination was ~9.21% compared to 6.06% in the max dose phentermine alone and 6.44% in the max dose topiramate alone groups and these findings were statistically significant. The 7.5/46 mg group was associated with ~8.46% weight loss from baseline.
What is the drug name for phentermine?
Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, amphetamine (d- and dll-amphetamine). Drugs of this class used in obesity are commonly known as “anorectics” or “anorexigenics.”
Is phentermine safe for obesity treatment?
Purpose: Phentermine is the most prescribed antiobesity drug in America, with 2.43 million prescriptions written in 2011. Case reports suggest there are anesthetic risks, such as refractory hypotension, involved with its perioperative use.
What is the connection between amphetamines and phentermine?
Phentermine is related chemically and pharmacologically to the amphetamines. Amphetamines and other stimulant drugs have been extensively abused and the possibility of abuse of Phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program.
Do phentermine cravings exist?
Significantly there was no evidence of phentermine cravings. Further investigation is warranted. The addiction potential of a drug may be investigated by measuring the drug’s propensity to induce dependence, to induce cravings for the drug, and for cessation of the drug to induce characteristic withdrawal symptoms.