What is the meaning of metalloproteinase?
(MAY-trix meh-TA-loh-PROH-tee-nays) A member of a group of enzymes that can break down proteins, such as collagen, that are normally found in the spaces between cells in tissues (i.e., extracellular matrix proteins). Because these enzymes need zinc or calcium atoms to work properly, they are called metalloproteinases.
What produces matrix metalloproteinases?
MMPs are produced by many cell types, including lymphocytes and granulocytes, but in particular by activated macrophages (17).
Where does MMP 13 come from?
MMP-13 (collagenase 3) belongs to the collagenase subgroup of the MMP family because of its structural similarity to MMP-1 (collagenase 1) and its ability to cleave interstitial fibrillar collagens. It was originally cloned from human breast cancer tissue [8].
Is there new hope for therapeutic matrix metalloproteinase inhibition?
MMPs are also known to be involved in several inflammatory processes, and there are new therapeutic opportunities for MMP inhibitors to treat such diseases.
What is another name for metalloproteinase?
Matrix metalloproteinase From Wikipedia, the free encyclopedia Matrix metalloproteinases (MMPs), also known as matrix metallopeptidases or matrixins, are metalloproteinases that are calcium -dependent zinc -containing endopeptidases; other family members are adamalysins, serralysins, and astacins.
What is extracellular matrix metalloproteinase?
Extracellular proteases are crucial regulators of cell function. The family of matrix metalloproteinases (MMPs) has classically been described in the context of extracellular matrix (ECM) remodelling, which occurs throughout life in diverse processes that range from tissue morphogenesis to wound healing.
How are metalloproteinases secreted?
Metalloproteinases are secreted as inactive zymogens with a structural propiece; the activation of these zymogens requires double proteolytic cleavage of the pro-domain at the N-terminal of the MMP.
What are metalloproteases from matrix?
Metalloproteases (MMPs) from matrix are proteolytic enzymes necessary to model the cell medium, recycling receptors, and other types of extracellular proteins. They are released as pro-enzymes, have the ion zinc as a cofactor, and are inhibited endogenously by tissue inhibitors of metalloproteases (TIMPs).