Who makes GM-CSF?
GM-CSF is produced by multiple cell types such as activated T cells, B cells, macrophages, monocytes, mast cells, vascular endothelial cells, and fibroblasts (2).
Where is GM-CSF made?
GM-CSF is produced by various cell types including macrophages, mast cells, T cells, fibroblasts and endothelial cells 8, 9, mostly in response to immune activation and cytokines that mediate inflammation.
What does GM-CSF stand for?
A substance that helps make more white blood cells, especially granulocytes, macrophages, and cells that become platelets. It is a cytokine that is a type of hematopoietic (blood-forming) agent. Also called granulocyte-macrophage colony-stimulating factor and sargramostim.
What is GM-CSF test?
The serum GM-CSF autoantibody ELISA test (GMAb ELISA) used to measure GM-CSF autoantibodies (Schoch et al., 2002) was recently optimized and found to have a sensitivity and specificity of 100% for diagnosis of autoimmune PAP (Uchida et al., 2014).
Is GM-CSF the same as G-CSF?
In summary, although G-CSF and GM-CSF are molecularly cloned myeloid growth factors, their biology and clinical effects differ. GM-CSF has a much wider activity spectrum in animals and humans. In persons with lung infection and/or ARDS, GM-CSF may be a safer drug than G-CSF.
Is GM-CSF pro inflammatory cytokine?
GM-CSF was first characterized as a pro-inflammatory cytokine due to its ability to stimulate plasminogen-dependent fibrinolysis activity in mouse macrophages (Hamilton and others 1980).
Is G-CSF and GM-CSF same?
The G-CSF receptor (G-CSFR; CD114) is a homo-oligo-dimer, whereas the GM-CSF receptor (GM-CSFR; CD116) is a hetero-oligo-dimer sharing a β-chain with the IL-3 and IL-5 receptors. The G-CSFR is expressed primarily on neutrophils and bone marrow precursor cells.
How does GM-CSF work?
GM-CSF is a monomeric glycoprotein that functions as a cytokine—it is a white blood cell growth factor. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.
When do you use CSF GM?
G-CSF is approved by the United States Food and Drug Administration (FDA) for use to decrease the incidence of infection in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a significant incidence of severe neutropenia with fever; reduce the time to neutrophil recovery …
How quickly does G-CSF work?
This usually takes 5 to 7 days, although it can be longer. If you are having G-CSF before a stem cell transplant, you usually have your first dose 4 to 6 days before your stem cells are going to be collected.
Is GM-CSF anti inflammatory?
However, a review of literature reveals that in many situations GM-CSF can act as an anti-inflammatory/regulatory cytokine. We and others have shown that GM-CSF can modulate dendritic cell differentiation to render them “tolerogenic,” which, in turn, can increase regulatory T-cell numbers and function.
Does Claritin help with bone pain from Neulasta?
Although Claritin (loratadine) has a minimal effect on pain it is well tolerated, inexpensive and easily administered so may be considered to help reduce bone pain in Neulasta patients.