Table of Contents
What are dendrimers in nanotechnology?
Abstract. Dendrimers represent a class of novel polymers having unique molecular architectures characterized by their well-defined structure, with a high degree of molecular uniformity, low polydispersity and properties that make them attractive materials for the development of nanomedicines.
What are the uses of dendrimers?
Due to their size, dendrimers are used in nanomedicine research. They are found to be useful as delivery or carrier systems for drugs and genes, but studies have shown that some dendrimers have medicinal uses of their own, mostly due to their antifungal, antibacterial and cytotoxic properties [5,6].
What is the meaning of Pamam?
Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.
What are PAMAM dendrimers?
PAMAM dendrimers are a family of highly branched and mono-disperse synthetic macromolecules with well-defined structures and compositions. Synthesis of these nanocarriers can be carried out through the divergent route.
What are the applications of dendritic polymers in pharmaceuticals?
There is a wide variety of potential applications of dendritic polymers. One of the most promising is utilization of polyamidoamine (PAMAM) dendrimers as drug delivery devices. Among pharmaceuticals that have been connected with different types of dendrimers are nonsteroidal anti-inflammatory drugs (NSAIDs), anticancer drugs and other.
What are dendrimers in biomedical field?
Dendrimers in biomedical field. Dendritic polymers have advantage in biomedical applications. These dendritic polymers are analogous to protein, enzymes, and viruses, and are easily functionalized. Dendrimers and other molecules can either be attached to the periphery or can be encapsulated in their interior voids [56].
Why do we synthesize dendrimers?
In contrast, the synthesis of dendrimers offers the chance to generate monodisperse, structure-controlled macromolecular architectures similar to those observed in biological systems [ 36, 37 ]. Dendrimers are generally prepared using either a divergent method or a convergent one [ 38 ].
What are the pharmacokinetic properties of dendrimers?
Pharmacokinetic properties are one of the most significant aspects that need to be considered for the successful biomedical application of dendrimers, for instance, drug delivery, imaging, photodynamic therapy, and neutron capture therapy. The diversity of potential applications of dendrimers in medicine results in increasing interest in this area.