Table of Contents
What is clindamycin made of?
CLEOCIN HCl Capsules contain clindamycin hydrochloride equivalent to 75 mg, 150 mg, or 300 mg of clindamycin. Inactive ingredients: 75 mg – corn starch, FD&C blue no. 1, FD&C yellow no. 5, gelatin, lactose, magnesium stearate, and talc; 150 mg – corn starch, FD&C blue no.
What are the properties of clindamycin?
Clindamycin is a lincosamide antibiotic with bacteriostatic properties against several obligate anaerobes. Binding of clindamycin to the 50S ribosomal subunit inhibits bacterial protein synthesis.
What type of antibiotic is clindamycin?
Clindamycin is a lincosamide antibiotic that has been approved by the US Food and Drug Administration for the treatment of anaerobic, streptococcal, and staphylococcal infections. Its major disadvantage is its propensity to cause antibiotic-associated diarrhea, including Clostridioides difficile colitis.
How does clindamycin reduce toxin?
Clindamycin acts by inhibiting bacterial protein synthesis at the level of the 50S ribosome. As a result, it exerts a prolonged postantibiotic effect. It may decrease toxin production and increase microbial opsonization and phagocytosis even at subinhibitory concentrations.
Is clindamycin a phosphate?
What Is Clindamycin Phosphate? Clindamycin phosphate topical solution is a topical (for the skin) antibiotic used to treat acne vulgaris. Clindamycin phosphate topical solution is available in generic form.
Is clindamycin an acid or a base?
Clindamycin is a very strong basic compound (based on its pKa). In humans, clindamycin is involved in clindamycin action pathway. Orally and parenterally administered clindamycin has been associated with severe colitis (pseudomembranous colitis) which may result in patient death.
What is the pH of clindamycin?
Clindamycin hydrochloride is freely soluble in water, in dimethylformamide, and in methyl alcohol. It is soluble in alcohol and practically insoluble in acetone. The pH of a 10% solution in water is between 3.0 and 5.5.
What’s the difference between amoxicillin and clindamycin?
Penicillin antibiotics, such as penicillin or amoxicillin, are most commonly used to treat tooth infections. Clindamycin can be useful if you’re allergic to or haven’t had success with penicillin antibiotics. It’s also active against a variety of bacteria.
What antibiotics inhibit toxin production?
The principal protein synthesis inhibitor (PSI) antibiotics that are active against S. aureus and reduce bacterial toxin production are clindamycin and linezolid.
How does clindamycin Phosphate work?
This medication is used to treat acne. It helps to decrease the number of acne lesions. Clindamycin is an antibiotic which works by stopping the growth of bacteria.
Is clindamycin phosphate a retinoid?
ZIANA Gel (clindamycin phosphate, tretinoin) is an antibiotic and retinoid combination medicine used for the skin treatment of acne in patients 12 years and older.
Is clindamycin and clindamycin phosphate the same thing?
Clindamycin phosphate is slowly hydrolyzed to clindamycin, with a hydrolysis half-life of between 3 minutes (1200 mg) and 1 minute (300 mg). About 10% of the drug is present in the serum after 8 hours in the form of clindamycin phosphate.
Is clindamycin bactericidal or bacteriostatic?
Clindamycin is bacteriostatic and does not cross the blood-brain barrier; it is not used alone in the treatment of endocarditis or other intravascular or CNS infections that can occur during S. aureus invasive infection. The poor taste of clindamycin suspensions can hamper adherence to oral therapy in outpatients.
Is clindamycin an acid or base?
Abstract. Clindamycin is concentrated within human neutrophils and their lysosomes because the intralysosomal pH is highly acidic and this antibiotic behaves as a weak base.
Is clindamycin acidic or basic?
Is doxycycline similar to clindamycin?
Doxycycline and clindamycin are different types of antibiotics. Doxycycline is a tetracycline antibiotic and clindamycin is a lincosamide antibiotic. Side effects of doxycycline and clindamycin that are similar include nausea, vomiting, diarrhea, and stomach/abdominal pain.
Does clindamycin inhibit cell wall synthesis?
Penicillin (PCN) works by inhibiting bacterial cell wall synthesis and replication. Clindamycin binds to the 50s ribosomal subunit and inhibits protein synthesis. As such, clindamycin “shuts down production of toxins”.
What is the concentration of clindamycin in diluent for infusion?
The concentration of clindamycin in diluent for infusion should not exceed 18 mg per mL. Infusion rates should not exceed 30 mg per minute. The usual infusion dilutions and rates are as follows:
What are the uses of clindamycin?
Clindamycin is used to treat serious infections caused by bacteria. Clindamycin may also be used for purposes not listed in this medication guide. Clindamycin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. If you have diarrhea that is watery or bloody, stop using this medicine and call your doctor.
What are the side effects of clindamycin?
Common adverse drug reactions associated with systemic clindamycin therapy – found in over 1% of people – include: diarrhea, pseudomembranous colitis, nausea, vomiting, abdominal pain or cramps and/or rash.
Is clindamycin a strong or weak antibiotic?
Is clindamycin a strong antibiotic? Medically reviewed by Sally Chao, MD. Last updated on May 12, 2021. Clindamycin is a strong broad-spectrum antibiotic, typically prescribed for serious infections, such as life-threatening methicillin-resistant Staphylococcus aureus (MRSA) skin infections.