What is sulfasalazine derived?
It derives from a sulfanilamide.
What is the generic name for sulfasalazine?
Sulfasalazine, Oral Tablet. Sulfasalazine oral tablets are available as both generic drugs and as brand-name drugs. Brand names: Azulfidine, Azulfidine EN-Tabs. Sulfasalazine only comes as oral tablets, which come in immediate-release and extended-release forms.
What drug class is sulfasalazine?
Sulfasalazine is in a class of medications called anti-inflammatory drugs.
Why is sulfasalazine prodrug?
Sulfasalazine is a prodrug composed of 5-aminosalicylic acid (5-ASA) linked to sulfapyridine through an azo bond (figure 1). Sulfasalazine is partially absorbed in the jejunum after oral ingestion.
What are the ingredients in sulfasalazine?
Sulfasalazine Tablets contain Sulfasalazine, 500 mg, for oral administration. Therapeutic Classification: Anti-inflammatory agent. Chemical Designation: 5-([p-(2-pyridylsulfamoyl)phenyl]azo) salicylic acid. Inactive ingredients: Corn starch, magnesium stearate, pregelatinized starch, stearic acid.
Is sulfasalazine a sulfa drug?
Sulfasalazine is in a type of sulfa drug. You should not take it if you have a sulfa allergy. Sulfasalazine is used in the treatment of rheumatoid arthritis (RA), inflammatory bowel disease, and some other autoimmune conditions. It works to lower inflammation in the body.
What is the other name of sulfasalazine?
Sulfasalazine (brand name: Azulfidine) and the 5-aminosalicylate drugs (sample brand names: Delzicol, Asacol HD, Pentasa, Salofalk, Dipentum, Colazal, Apriso, Lialda) are used to treat inflammatory bowel disease.
Is sulfasalazine a biologic?
DMARDs are immunosuppressive and immunomodulatory agents and are classified as either conventional DMARDs or biologic DMARDs. Commonly used conventional DMARDs include methotrexate, leflunomide, hydroxychloroquine, and sulfasalazine.
Is sulfasalazine an aspirin?
Sulfasalazine (Azulfidine), used to treat pain and swelling in arthritis, belongs to a class of drugs called sulfa drugs. It is a combination of salicylate (the main ingredient in aspirin) and a sulfa antibiotic.
Can I take sulfasalazine if I am allergic to sulfa?
Sulfasalazine and sulfa allergies — People who are allergic to sulfa drugs may have a cross reaction to sulfasalazine and should therefore not take it.
Are hydroxychloroquine and sulfasalazine similar?
Azulfidine (Sulfasalazine) Treats malaria and autoimmune conditions including rheumatoid arthritis and lupus. Plaquenil (hydroxychloroquine) is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Reduces inflammation.
Do you need to take folic acid with sulfasalazine?
Sulfasalazine can affect folate absorption, so you should also take folic acid (1 mg per day) while taking the medication and if you are pregnant, you should take 2 mg of folic acid a day.
Can you take vitamin C with sulfasalazine?
No interactions were found between sulfasalazine and Vitamin C.
What is alternative for sulfasalazine?
Sulfasalazine Alternatives Compared
| Sulfasalazine | Methotrexate | Enbrel etanercept |
|---|---|---|
| Lower-cost generic is available | Lower-cost generic is available | No lower-cost generic available |
| Availability | ||
| Prescription only | Prescription only | Prescription only |
| Ratings & Reviews |
What is the chemical classification of sulfasalazine?
The chemical classification of sulfasalazine is Aminosalicylic Acids. Sulfasalazine is an antiinflammatory agent used extensively in chronic, long term therapy of inflammatory bowel disease. Sulfasalazine is structurally composed of a sulfonamide (sulfapyridine) and 5-aminosalacyclic acid (5-ASA) joined by an azo bond.
How is sulfasalazine broken down in the body?
The medication is broken down by intestinal bacteria into sulfapyridine and 5-aminosalicylic acid. That which is absorbed is excreted by the kidneys and in the bile. Sulfasalazine was approved for medical use in the United States in 1950.
What is the USP for sulfasalazine 500 mg?
Sulfasalazine Tablets, USP 500 mg, are round, scored, light brown tablets, debossed with “CE” above the functional score and “33” below the functional score on one side and plain on the other side, supplied as : Store at controlled room temperature 15–30° C (59–86° F).
Does sulfasalazine cause sulfhemoglobinemia?
Sulfasalazine may cause sulfhemoglobinemia. Around 90% of a dose of sulfasalazine reaches the colon, where most of it is metabolized by bacteria into sulfapyridine and mesalazine (also known as 5-aminosalicylic acid or 5-ASA).