Table of Contents
What is the difference between pilocarpine and cevimeline?
Pilocarpine is a nonselective muscarinic agonist, whereas cevimeline reportedly has a higher affinity for M1 and M3 muscarinic receptor subtypes. Because M2 and M4 receptors are located on cardiac and lung tissues, cevimeline’s M1 and M3 specificity suggests there will be fewer cardiac and/or pulmonary side effects.
Is Evoxac an anticholinergic?
Cevimeline (Evoxac) is a cholinergic agonist. It stimulates (triggers) your salivary glands to produce more saliva.
Is cevimeline an anticholinergic?
Cevimeline is used to treat the symptoms of dry mouth in patients with Sjogren’s syndrome (a condition that affects the immune system and causes dryness of certain parts of the body such as the eyes and mouth). Cevimeline is in a class of medications called cholinergic agonists.
Does pilocarpine cause bradycardia?
Use of pilocarpine may result in a range of adverse effects, most of them related to its non-selective action as a muscarinic receptor agonist. Pilocarpine has been known to cause excessive salivation, sweating, bronchial mucus secretion, bronchospasm, bradycardia, vasodilation, and diarrhea.
What are the side effects of cevimeline?
Side Effects
- Bladder pain.
- bloody or cloudy urine.
- body aches or pain.
- difficult, burning, or painful urination.
- difficulty in breathing.
- dryness or soreness of the throat.
- ear congestion.
- frequent urge to urinate.
Does Evoxac help dry eyes?
Oral Evoxac was approved for the treatment of dry mouth in patients who have Sjgrens syndrome. The drugs primary function is to augment salivary flow rates, but it has also been shown to improve dry eye symptoms.
What drugs block the parasympathetic nervous system?
Muscarinic receptor antagonists oppose the actions of the parasympathetic nervous system. Examples of antagonists include atropine and hyoscine (scopolamine) which are found in the plants Atropa belladonna and Datura stramonium.
What drugs activate the parasympathetic nervous system?
Parasympathomimetics are a class of medications that activate the parasympathetic nervous system by mimicking or modifying the effects of acetylcholine. These drugs include muscarinic receptor agonists (direct-acting parasympathomimetics) and acetylcholinesterase inhibitors (indirect-acting parasympathomimetics).
What is the effect of pilocarpine on heart rate?
Acetylcholine and Pilocarpine slowed the heart rate when they were applied. Conversely, the addition of Epinephrine and Atropine + Acetylcholine increased the heart rate.
What are the contraindications of pilocarpine?
The following conditions are contraindicated with this drug….Who should not take PILOCARPINE HCL?
- mental problems.
- detachment of the retina of the eye.
- inflammation of the iris – the colored part of the eyeball.
- closed angle glaucoma.
- high blood pressure.
- low blood pressure.
- asthma attack.
- bronchospasm.
Does Sjogren’s syndrome go away?
There’s currently no cure for Sjögren’s syndrome, but there are several treatments that can help, such as: eye drops that keep your eyes wet (artificial tears) sprays, lozenges (medicated sweets) and gels that keep your mouth wet (saliva substitutes) medicine that helps your body produce more tears and saliva.
What is Evoxac used to treat?
Evoxac (cevimeline hydrochloride) is a cholinergic agonist that works by stimulating certain nerves to increase the amount of saliva produced used to treat dry mouth in people with Sjogren’s Syndrome. Evoxac is available in generic form. What are side effects of Evoxac? Common side effects of Evoxac include:
What are the side effects of Evoxac?
Evoxac side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Evoxac and call your doctor at once if you have:
When is a pacemaker not indicated in the treatment of bradycardia?
A pacemaker is not indicated for sinus node dysfunction in patients with symptoms suggestive of bradycardia that have been documented to occur even in the absence of bradycardia. Asymptomatic second-degree Mobitz, type-I block Asymptomatic prolonged RR interval with atrial fibrillation or other causes of transient ventricular pauses
When is pacing indicated in patients with atrioventricular (AV) block 1?
With regards to AV block I, pacing is indicated if symptoms of hemodynamic compromise exist; this is generally related to extreme prolongation in PR interval (>0.3 seconds), which results in atrioventricular (AV) desynchronization.