Table of Contents
What is the meaning of Toxicodynamics?
Toxicodynamics refer to the quantitative description of the effects of a toxicant on a biological system. These effects include a range of endpoints and products, ranging from the molecular level, to cells, tissues, organ systems, and life-history traits.
Who is the father of toxicology?
Mathieu Joseph Bonaventure Orfila
Mathieu Joseph Bonaventure Orfila (1787–1853), often called the “Father of Toxicology,” was the first great 19th-century exponent of forensic medicine. Orfila worked to make chemical analysis a routine part of forensic medicine, and made studies of asphyxiation, the decomposition of bodies, and exhumation.
What’s the difference between PK and TK?
PK is the abbreviation for pharmacokinetics. TK is the abbreviation for toxicokinetics. Some consider these to be distinct specialties while others consider them to be the same.
Is TK required in CA?
Both TK and kindergarten are entirely optional. Children are only required to attend school in California once they turn 6. Until that age, it is up to parents to decide whether to enroll their children in preschool or transitional kindergarten or other child care arrangements or keep them at home. 2.
What is toxicodynamics?
The term “toxicodynamics” describes what a toxicant does physiologically, biochemically, and molecularly to an animal’s body following exposure.
What are the pharmacokinetics and toxicokinetics of a therapeutic xenobiotic?
The pharmacokinetics and pharmacodynamics of a therapeutic xenobiotic influence the time course and efficacy of that compound in a pharmacological setting. Likewise, the toxicokinetics and toxicodynamics of a toxic xenobiotic determine the “when,” “how long,” “what,” and “why” for the adverse effects of that toxicant. 2
What determines the “disposition” of a toxic xenobiotic?
Likewise, the toxicokinetics and toxicodynamics of a toxic xenobiotic determine the “when,” “how long,” “what,” and “why” for the adverse effects of that toxicant. 2 The “disposition” of a xenobiotic is what the animal’s body does to that compound following exposure.
Do toxicodynamic parameters cluster according to chemical class or moa?
We found that toxicodynamic parameters cluster according to chemical class. Clustering of toxicodynamic parameters according to chemical MOA is more pronounced for GUTS-IT (panels C, D) than for GUTS-SD (panels A, B).