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What is Immunophenotypic analysis?
Listen to pronunciation. (IH-myoo-noh-FEE-noh-ty-ping) A process that uses antibodies to identify cells based on the types of antigens or markers on the surface of the cells. This process is used in basic research and to help diagnose diseases, such as specific types of leukemia and lymphoma.
Are Hematogones normal?
Definition. Hematogones are benign lymphoid precursors whose morphology and immunophenotype are similar to the blasts found in ALL. These cells are more commonly found in pediatric bone marrow aspirates following therapy.
What can immunophenotyping diagnose?
Immunophenotyping is used primarily to help diagnose and classify the blood cell cancers, leukemias and lymphomas, and to help guide their treatment.
Why is Immunophenotypic analysis important?
Analysis is also useful for subclassifying certain lymphoma subtypes, which has therapeutic and prognostic importance. Immunophenotypic analysis helps to distinguish reactive from neoplastic lymphoid infiltrates, lymphoid from nonlymphoid malignancies, and specific lymphoid neoplasms.
How is lymphoma detected?
Blood tests to count the number of cells in a sample of your blood can give your doctor clues about your diagnosis. Removing a sample of bone marrow for testing. A bone marrow aspiration and biopsy procedure involves inserting a needle into your hipbone to remove a sample of bone marrow.
What does dim positive mean?
The recommended descriptions of antibody fluorescence intensity are “dim” for a uniformly positive population with lower mean fluorescence intensity than a positive normal cell population, “bright” for a uniformly positive population with higher intensity than the control, and “heterogeneous” for antigens that show …
Can a bone scan detect lymphoma?
Lymphoma often causes bone damage, which may be seen on a bone scan. But bone scans can’t show the difference between cancers and non-cancerous problems, such as arthritis and fractures, so further tests might be needed.