What is Oncofetal gene?
Oncofetal genes are defined as genes expressed in the embryos or fetuses, which are turned off or suppressed in adult tissue, but re-expressed in tumor cells (Cleynen et al., 2007; Sarandakou et al., 2007). Most are clinically useful markers or functionally interesting genes.
What is oncofetal proteins?
A Oncofetal Proteins Oncofetal proteins originate within tumor cells and enter the bloodstream either by secretion from the tumor or as a breakdown product of tumor cells. Normally oncofetal proteins are present during embryogenesis and may increase with certain cancers, making them potentially useful tumor markers.
How are oncofetal antigens used?
Oncofetal antigens are proteins which are typically present only during fetal development but are found in adults with certain kinds of cancer. These proteins are often measurable in the blood of individuals with cancer and may be used to both diagnose and follow treatment of the tumors.
Which tumor marker is an oncofetal antigen?
Alpha-fetoprotein (AFP) is an oncofetal antigen that is useful in monitoring patients with nonseminomatous testicular cancer and certain types of ovarian cancer.
What are Oncofetal markers?
Is PSA an oncofetal antigen?
Some of the common oncofetal antigens used as biomarkers in oncology include cancer antigen 125 (CA125), CA19-9, prostate-specific antigen (PSA) and α-fetoprotein (AFP)27,28,29.
What are oncofetal markers?
Why is it called an oncofetal antigen?
Because of the fact that it is primarily expressed by fetal tissues and malignant tumours, it is referred to as an oncofetal antigen. ASN004 is an Antibody Drug Conjugate that targets the 5T4 oncofetal antigen, which is expressed in a wide range of malignant tumors but has very limited expression in normal tissues.
What is an oncogene?
An oncogene is a mutated gene that contributes to the development of a cancer. In their normal, unmutated state, onocgenes are called proto-oncogenes, and they play roles in the regulation of cell division. Some oncogenes work like putting your foot down on the accelerator of a car, pushing a cell to divide.
What is the role of oncogenes in cell division?
In their normal, unmutated state, onocgenes are called proto-oncogenes, and they play roles in the regulation of cell division. Some oncogenes work like putting your foot down on the accelerator of a car, pushing a cell to divide.