What is a tolerogenic response?
Tolerogenic therapy aims to induce immune tolerance where there is pathological or undesirable activation of the normal immune response.
Is tolerogenic response an antigen specific?
Tolerogenic antigen-presenting cells (APCs) are attractive agents for the treatment of autoimmune and inflammatory diseases that are mediated, at least in part, by antigen-specific autoreactive T cells.
What are tolerogenic DCs?
Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens.
What is tolerogenic cell death?
The tolerogenic effect of cell death depends on many factors, including the absence of T cell help, the location of the dying cells (which in part dictates their engulfment by distinct dendritic cell (DC) subtypes), the maturation state of the DC, the production of immunosuppressive factors (such as transforming growth …
Are autoimmune diseases more common in females?
Women are less susceptible to infectious diseases than men, but are more often prone to autoimmune diseases. This higher prevalence is partly attributable to the X chromosome, which has many genes relating to the immune system.
What is tolerogenic phenotype?
Tolerogenic DCs often display an immature or semi-mature phenotype that is characterized by low expression of co-stimulatory and MHC molecules and altered cytokine production.
How can I improve my innate immune system?
These strategies might include:
- eating a diet rich in fruits and vegetables.
- exercising regularly.
- maintaining a healthy weight.
- quitting smoking.
- drinking alcohol only in moderation.
- getting enough sleep.
- avoiding infection through regular hand washing.
- reducing stress.
What helps activate our innate immune system?
The innate immune system is activated by the presence of antigens and their chemical properties.
What is an idiotypic network?
The idiotype network is a complex cascade of antibodies. Normally, after antibodies are produced in response to antigen, antiidiotypic antibodies arise. These anti-idiotypes can bind to all antibodies bearing the specific idiotypic determinant, independent of their antigenic specificity.
What is Tolergen?
A foreign antigen that suppresses immune response, or produces immune tolerance. Supplement.
What is B cell tolerance?
B cell tolerance is a state in which B cells do not initiate an immune response to an antigen. Typically this term refers to absence of recognition of self antigens.
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