Table of Contents
What is suppositories and pessaries?
“Suppositories are solid, single-dose preparations. The shape, volume and consistency of suppositories are suitable for rectal administration.” Page 10. ► Pessaries are a type of suppository intended for. vaginal use.
What is pessaries in pharmaceutics?
A pessary is a prosthetic device inserted into the vagina for structural and pharmaceutical purposes. It is most commonly used to treat stress urinary incontinence to stop urinary leakage and to treat pelvic organ prolapse to maintain the location of organs in the pelvic region.
What is suppositories in pharmacy?
Listen to pronunciation. (suh-PAH-zih-TOR-ee) A form of medicine contained in a small piece of solid material, such as cocoa butter or glycerin, that melts at body temperature. A suppository is inserted into the rectum, vagina, or urethra and the medicine is absorbed into the bloodstream.
What is a suppository used for?
Rectal suppositories are forms of medication that are inserted into the rectum. They come in different shapes and sizes but are usually narrowed at one end. Rectal suppositories can deliver many types of medication. For instance, they may contain glycerin to treat constipation or acetaminophen to treat a fever.
Why is it called a suppository?
Suppositories are a dosage form designed to deliver drugs through rectal and vaginal routes of administration. They evolved as a more convenient alternative form of drug delivery from liquid enema formulations. In fact, the term suppositorium comes from the Latin word supponere, meaning ‘substitute’ [1].
What are the advantages of suppository?
It also helps to deliver drugs across a restricted area with reduced systemic effects. Reduce systemic toxicity by delivering the drug to the target site of action in a lower dose. Very helpful for hemorrhoids and vaginal infections. Effective long-term treatment.
What is suppository base?
Suppository base excipients are used in the manufacture of suppositories (for rectal administration) and pessaries (for vaginal administration). They can be hydrophobic or hydrophilic. Suppositories should melt at just below body temperature (37 C), which allows for erosion of the dosage form and release of the API.
What are the benefits of suppositories?
The primary advantages of suppositories over other dosage forms include reduced first pass metabolism, both topical and systemic effect, accommodates patients who have difficulty swallowing pills, and increased bioavailability of drugs.
What is suppository PDF?
Suppositories: “Suppositories are solid bodies of various weights and shapes, adapted for introduc- tion into the rectal, vaginal, or urethral orifice of the human body.They usually melt, soften, or. dissolve at body temperature. A suppository may act as a protectant or palliative to the local tis-
What is suppositories and its classification?
Traditionally cylindrical in shape, suppositories can be classified into two base types: lipophilic and hydrophilic. Lipophilic suppositories are primarily fat- or wax-based and melt at human body temperature. Hydrophilic suppositories are polymer or glycerin based and require fluids to dissolve.
What is the most commonly used suppository?
The most frequently used suppository bases, especially: 1) cocoa butter. 2) hydrogenated fatty acids of vegetable oils, such as palm kernel oil and cottonseed oil. 3) compounds consisting of glycerides of higher- molecular-weight fatty acids, such as glyceryl monostearate and glyceryl monopalmitate.
What are suppository bases?
What is the difference between suppositories and pessaries?
DEFINITION A suppository is a medicated solid dosage form generally intended for use in the rectum, vagina and to a lesser extent, the urethra. After insertion they melt or soften at body temperature, whereas vaginal suppositories sometimes called as pessaries, are also made as compressed tablets that disintegrate in body fluids. 2
2. DEFINITION A suppository is a medicated solid dosage form generally intended for use in the rectum, vagina and to a lesser extent, the urethra. After insertion they melt or soften at body temperature, whereas vaginal suppositories sometimes called as pessaries, are also made as compressed tablets that disintegrate in body fluids. 2
What are the bases used in the preparation of suppositories?
The bases used, most commonly, for extemporaneous preparation of suppositories and pessaries are the synthetic fats and glycerol-gelatin base. 1. When calculating the quantity of ingredients it is necessary to prepare excess due to unavoidable wastage.
What is a pessary and how does it work?
A pessary is a prosthetic device that can be inserted into the vagina to support its internal structure. It’s often used in the case of urinary incontinence and a vaginal or pelvic organ prolapse.