Table of Contents
Is HCV genotype 1a curable?
One of these drugs is sofosbuvir. With PEG/ribavirin treatment alone, genotype 1 HCV used to require the longest duration of treatment with the least likelihood of success. With sofosbuvir, genotype 1 is now curable in more than 95 percent of people treated for only 12 weeks.
What does HCV Ab positive mean?
What does a reactive HCV antibody test result mean? ► A reactive or positive antibody test means you have been infected with the hepatitis C virus at some point in time. ► Once people have been infected, they will always have antibodies in their blood.
Which medication is only approved for genotype 1 treatment of HCV?
Ledipasvir/sofosbuvir (400 mg sofosbuvir/90 mg ledipasvir co-formulated in a single tablet) was approved by the FDA in October 2014 for the treatment of genotype 1 infection.
What is genotype 1 hepatitis C (HCV)?
In the United States, genotype 1 hepatitis C virus (HCV) accounts for approximately 70 to 75% of all HCV infections. Accordingly, treatment of genotype 1 has the most extensive data and highest clinical relevance for hepatitis C treatment issues in the United States.
What is the US prevalence of human hepatocellular virus (HCV) infection?
( 1) Approximately 75% of Americans with HCV have genotype 1 of the virus (subtypes 1a or 1b), and 20-25% have genotypes 2 or 3, with small numbers of patients infected with genotypes 4, 5, or 6.
What is the best treatment for HCV genotype 1?
Studies of Initial Treatment of Adults with HCV Genotype 1 1 Elbasvir-Grazoprevir. The study enrollment included 288 patients with genotype 1 infection. 2 Glecaprevir-Pibrentasvir. Among those enrolled, 33 were coinfected with HIV. 3 Ledipasvir-Sofosbuvir. 4 Sofosbuvir-Velpatasvir-Voxilaprevir.
Is ribavirin necessary for the treatment of hepatitis C genotype 1?
As of 2017, there have been multiple safe, convenient, and highly effective all-oral regimens recommended for the treatment of HCV genotype 1, most of which do not require ribavirin.