What does triple whammy cause?
The mechanism of the triple whammy NSAIDs are associated with an increased risk of AKI, due to blockade of the COX-2 enzyme preventing prostacyclin synthesis, which causes afferent arteriolar vasoconstriction.
Why are ACE inhibitors not OK for kidney patients?
Although ACE inhibitor therapy usually improves renal blood flow (RBF) and sodium excretion rates in CHF and reduces the rate of progressive renal injury in chronic renal disease, its use can also be associated with a syndrome of “functional renal insufficiency” and/or hyperkalemia.
Can lisinopril cause kidney pain?
Because ACE inhibitors are metabolized by the kidneys, they do come with a risk of causing kidney damage, especially if you are dehydrated, which is often the case in people with existing kidney problems—like chronic kidney disease.
Which NSAID is worse for kidneys?
Etoricoxib had the largest negative effect on kidney function. Its use was significantly associated with a 3.1-fold increased risk of both incident eGFR less than 60 and eGFR decline of 30% or greater as well as the composite of either outcome.
What blood pressure medicine is easiest on the kidneys?
ACE inhibitors and ARBs are two types of blood pressure medicine that may slow the loss of kidney function and delay kidney failure. You can tell if you’re taking one of these medicines by its generic name.
What blood pressure meds can cause kidney damage?
Popular diuretics include hydrochlorothiazide, furosemide, and spironolactone. They are associated with a risk for acute kidney injury.
What blood pressure medicine does not affect the kidneys?
What blood pressure medications cause kidney failure?
Can lisinopril worsen kidney function?
Long-Term Use of ACE Inhibitors May Cause Kidney Damage, Study Results Suggest. New research raises concerns about the commonly prescribed medications used to treat heart failure and high blood pressure, though investigators say patients should continue to take them.
Is kidney damage caused by NSAIDs reversible?
Generally, the renal failure with NSAIDs is acute and reversible, though analgesic nephropathy with papillary necrosis and chronic renal failure are reported.
What is Aki triple whammy syndrome?
Acute kidney injury and the triple whammy syndrome. The term acute kidney injury (AKI) encompasses a number of aetiopathologically heterogeneous conditions leading to an abrupt decline in renal excretory function causing azotaemia, alterations in urinary flow (typically oliguria), or both.
What is the triple whammy model of hypoperfusion?
The triple whammy was the only model associated with pre-renal AKI accompanied by a course of other risk factors, among numerous potential combinations of clinical circumstances causing hypoperfusion in which renal autoregulation is not operative or is deregulated.
Are You at risk of triple whammy high?
The concurrent use of an ACE inhibitor/ARB and a diuretic is a common combination of medicines in general practice, making the risk for triple whammy high. The figure and table below show the number of patients with these combinations of medicines and your rate of prescribing compared to other prescribers in New Zealand.
What are the risk factors for triple whammy-induced acute kidney injury?
Risk factors for triple whammy-induced AKI are similar to other forms of kidney injury and include: 3–5 1 Any stage of chronic kidney disease (CKD) 2 Older age, e.g. over 75 years 3 Volume depletion, e.g. due to vomiting, diarrhoea, sepsis or low fluid intake 4 Māori, Pacific or Indo-Asian ethnicity 5 Diabetes 6 Heart failure 7 Liver disease