Table of Contents
What drugs does ampicillin interact with?
Ampicillin has no known severe interactions with other drugs. Serious Interactions of ampicillin include: BCG vaccine live. cholera vaccine….Mild interactions of ampicillin include:
- allopurinol.
- atenolol.
- azithromycin.
- bendroflumethiazide.
- chloramphenicol.
- chlorothiazide.
- clarithromycin.
- colestipol.
Is pivampicillin more lipophilic than ampicillin?
Ampicillin pivaloyloxymethyl ester (pivampicillin) does not form zwitterion and displays relatively good solubility in water, although it is much more lipophilic than ampicillin. Consequently, the oral bioavailability of pivampicillin is almost twice that of ampicillin.
What can you not mix with ampicillin?
Before taking ampicillin, Be sure to mention any of the following: allopurinol (Lopurin, Zyloprim), other antibiotics, oral contraceptives, and probenecid (Probalan in Col-Probenecid,). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
Does ampicillin interact with ibuprofen?
Interactions between your drugs No interactions were found between ampicillin and ibuprofen. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider.
What is the side effects of ampicillin?
Common side effects of ampicillin may include: nausea, vomiting, stomach pain, diarrhea; rash; swollen, black, or “hairy” tongue; or. vaginal itching or discharge.
What happens when a drug is too lipophilic?
It is often observed that drugs that are in the early stages of development have high lipophilicity. This often leads to compounds that have a high rate of metabolism, leading to poor solubility, high turn-over, and low absorption. Very high levels of lipophilicity can also lead to toxicity and metabolic clearance.
How does lipophilicity affect drug absorption?
As well as affecting the absorption and metabolism of a drug, lipophilicity also influences its binding and distribution. Generally, the higher the lipophilicity of a drug, the stronger its binding to protein and the greater its distribution.
Which antibiotics are inhibited by clavulanic acid?
Clavulanic acid is a potent inhibitor of many β-lactamases, including those found in Escherichia coli (plasmid mediated), Klebsiella aerogenes, Proteus mirabilis, and Staphylococcus aureus, the inhibition being of a progressive type.
Can I take penicillin with other medications?
If you need to ease pain or lower a fever while you’re taking penicillin, it’s fine to take over-the-counter painkillers such as paracetamol or ibuprofen. Penicillin doesn’t affect hormonal contraceptives such as the pill.