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What is simvastatin equivalent to atorvastatin?
In controlled dosing studies, simvastatin 40 mg and atorvastatin 10 mg and 20 mg are equally effective. Simvastatin 40 mg lowers plasma concentrations of low density lipoprotein (LDL) cholesterol by 3% more than atorvastatin 10 mg and 4% less than atorvastatin 20 mg.
What are the dosages for statins?
Table 1Statin Dosing and ACC/AHA Classification of Intensity
| Statin | Dosage | |
|---|---|---|
| Low-intensity (LDL-C reduction <30%) | Moderate-intensity (LDL-C reduction 30% to <50%) | |
| Lovastatin | 20 mg | 40 mg |
| Pitavastatin | 1 mg | 2 to 4 mg |
| Pravastatin | 10 to 20 mg | 40 to 80 mg |
Can you substitute atorvastatin for rosuvastatin?
Trials in patients with hypercholesterolaemia have shown that rosuvastatin is more effective than atorvastatin at reducing LDL-C and achieving US and/or European LDL-C goals over treatment periods ranging from 6 to 52 weeks [25-30].
Is 5 mg statin effective?
This paper reviews key clinical results for a new agent, rosuvastatin. The data show that rosuvastatin 5 mg is highly effective in lowering LDL-C to recommended levels for most patients (mean reductions ranging from 42 to 52%).
Is it OK to switch from Lipitor to Crestor?
Sept. 5, 2007 — Patients who switch from the statin drug Lipitor to a generic version of another statin may be more likely to suffer strokes, heart attacks, and death, a new study from Lipitor manufacturer Pfizer shows.
What is a good substitute for atorvastatin?
7 cholesterol-lowering alternatives to statins
- Fibrates. Mostly used for lowering triglyceride levels in patients whose levels are very high and could cause pancreatitis.
- Plant stanols and sterols.
- Cholestyramine and other bile acid-binding resins.
- Niacin.
- Policosanol.
- Red yeast rice extract (RYRE)
- Natural products.
Which is stronger atorvastatin or rosuvastatin?
At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table 2).
What is the mildest statin?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
What is the lowest dose of statin?
“Leqvio is a revolutionary approach to lower LDL-C and creates new possibilities for how health care systems can impact cardiovascular disease, a defining public health challenge of our time,” said Vas Narasimhan, MD, CEO of Novartis, in the press release.
What is a normal statin dose?
Usual Adult Dose for Prevention of Cardiovascular Disease Initial dose: 10 mg or 20 mg orally once a day -An initial dose of 40 mg may be used in patients who require a larger reduction in low density lipoprotein (e.g. more than 45%) -Individualize dose based on goals of therapy and response
What is the average dosage of statins?
Coronavirus patients taking statins prior were 66 years old on average, and most patients (71%) had high blood pressure, cardiovascular disease, or both. Over 80% of all patients taking statins were also taking at least one drug to treat high blood
When to increase statin dose?
Statins do not boost recovery from COVID-19 and may actually increase risk for death in those with severe disease, according to a new study. File Photo by ragonmages/Shutterstock