Table of Contents
What is the target of a drug?
The Oxford Dictionary of Biochemistry and Molecular Biology defines a drug target as “a biological entity (usually a protein or gene) that interacts with, and whose activity is modulated by, a particular compound.”
What are the various methods of drug discovery?
For drug discovery, two different complementary approaches can be applied: classical pharmacology, also known as phenotypic drug discovery, which is the historical basis of drug discovery, and reverse pharmacology, also designated target-based drug discovery.
What is drug target validation?
Target validation ensures that engagement of the target has potential therapeutic benefit; like target identification, this is a critical step in drug development. If a target cannot be validated, then it will not proceed in the drug development process.
What is target discovery and validation?
The first stage of drug development is target discovery, also known as target identification and validation, the process of identifying a potential target for a therapeutic drug for a particular disease or condition that does not have a treatment or for which existing therapeutic agents are lacking in some way.
What is target identification?
Target identification is the process of identifying the direct molecular target – for example protein or nucleic acid – of a small molecule. In clinical pharmacology, target identification is aimed at finding the efficacy target of a drug/pharmaceutical or other xenobiotic.
What makes a good drug target?
Target has a favorable ‘assayability’ enabling high throughput screening. Target expression is not uniformly distributed throughout the body. A target/disease-specific biomarker exists to monitor therapeutic efficacy.
What are pharmacodynamic targets?
The target principle of dosing The target approach links pharmacokinetics (PK) with pharmacodynamics (PD) to predict the right dose for a patient. [1] Once a medicine has been chosen to achieve a desired clinical response, the target effect for the patient should then be established.
What is the purpose of drug discovery?
The goal of a preclinical drug discovery program is to deliver one or more clinical candidate molecules, each of which has sufficient evidence of biologic activity at a target relevant to a disease as well as sufficient safety and drug-like properties so that it can be entered into human testing.
What is drug discovery in pharmacology?
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered by identifying the active ingredient from traditional remedies or by serendipitous discovery, as with penicillin.