Table of Contents
How do dendrimers deliver drugs?
Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach.
How do dendrimers work?
In the different methods, dendrimer grows outward from a multifunctional core molecule. The core molecule reacts with monomer molecules containing one reactive and two dormant groups, giving the first-generation dendrimer. Then, the new periphery of the molecule is activated for reactions with more monomers.
What is non erodible insert?
Non erodible osmotic inserts : Single reservoir of drug with or without additional osmotic solute dispersed thro out polymeric matrix.
What is an Ocusert?
Ocuserts are the new drug delivery systems which are designed in such a way that they release the drug at predetermined and predictable rates thus eliminating the frequent administration of the drug.
What is ocular route?
Ocular drug delivery system (ODDS) is a dosage form, vehicle, or system intended for instilling, administering, or delivering drug/medicine to eye against any ailment or disorder involving or affecting vision. From: Drug Delivery Devices and Therapeutic Systems, 2021.
What is the application of dendrimers as a drug delivery system?
Application of dendrimers as a drug delivery system started in late 1990s. Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct.
Why are dendrimers so popular?
Due to their multivalent & monodisperse character,dendrimers have stimulated wide interest in the field of chemistry & biology, especially in applications like drug delivery, gene therapy & chemotherapy
What are PAMAM dendrimers?
PAMAM dendrimers were first reported by Tomalia in 1985 [3,4]. PAMAM dendrimers are one of the most used dendrimers for drug delivery systems [5,6,7].
Can PAMAM dendrimers enhance aqueous solubility and dissolution?
Conclusions We have demonstrated that PAMAM dendrimers can enhance aqueous solubility, stability, dissolution, drug release, targeting and pharmacokinetics of various drugs. The future of drug delivery would be fabricating ‘nano-robots’ capable of doing multiple jobs inside the body.