Table of Contents
What are the symptoms of NLPHL?
Symptoms for NLPHL may include:
- Lump in the neck, groin or armpit that doesn’t go away (usually painless)
- Unexplained fatigue.
- Excessive nighttime sweating.
- Weight loss.
- Ongoing high fevers.
How many people have NLPHL?
Results: We identified 1,937 cases of NLPHL. The majority were younger than 65 years (86%), white (70%), male (67%), and diagnosed between 2001-2015 (85%), when rituximab was introduced. Of all cases, 1336 (69%) were classified as early stage.
What are the side effects of chemotherapy for lymphoma?
Possible side effects of chemotherapy
- Hair loss.
- Mouth sores.
- Loss of appetite.
- Nausea and vomiting.
- Diarrhea.
- Increased chance of infection (from having too few white blood cells)
- Easy bruising or bleeding (from having too few blood platelets)
- Fatigue (from having too few red blood cells)
Is NLPHL curable?
NLPHL is curable, but people may relapse years after complete remission. Very rarely, NLPHL can progress into an aggressive type of NHL called diffuse large B-cell lymphoma. NLPHL is uncommon, only accounting for 5 percent of all cases of HL.
How do you treat NLPHL?
If early-stage NLPHL is bulky (large)or is causing B symptoms, the main treatment is usually chemotherapy followed by radiation therapy (ISRT). Many doctors use the ABVD chemo regimen, but some doctors prefer others. The monoclonal antibody rituximab (Rituxan®) might be given along with the chemotherapy.
Does chemo permanently damage your body?
The side effects of chemotherapy can linger for months and sometimes years. It depends on your overall health and the type of chemotherapy you receive as treatment. Some complications of chemotherapy are permanent. These can include damage to your respiratory, circulatory, sensory, excretory, and reproductive systems.
How effective is ABVD for Hodgkin’s lymphoma?
With ABVD as the initial therapy, approximately 75% of advanced-stage Hodgkin lymphoma patients obtain a complete response, and the 5-year failure-free survival rate is 75%. “If you are in this 75% group, you can get away with less therapy and far less long-term toxicity,” Dr.
How is NLPHL 2020 treated?
First-line treatment of stage IA NLPHL usually consists of limited-field radiotherapy alone. Patients with early-stage NLPHL other than stage IA and intermediate-stage disease mostly receive combined-modality treatment, whereas individuals with advanced NLPHL are treated with chemotherapy alone.
What is NLPHL?
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare type of Hodgkin lymphoma (HL) that tends to grow more slowly than classic HL (cHL).
How do I treat NLPHL?
What is NLPHL (nodular lymphocyte predominant Hodgkin lymphoma)?
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a type of Hodgkin disease, a cancer of lymph cells.
Quick overview of NLPHL. This section is an overview of the information on this page. There is more detail in the sections below. NLPHL is a rare, slow-growing type of lymphoma. It is a type of cancer where the abnormal cells are lymphocytes (a type of white blood cell).
What is the difference between NLPHL and transformed lymphoma?
Transformed lymphoma needs stronger treatment than NLPHL. It is usually treated like a type of fast-growing (high-grade) non-Hodgkin lymphoma called diffuse large B-cell lymphoma (DLBCL). Transformed NLPHL often responds well to treatment and many people go into complete remission (no sign of lymphoma on tests or scans).
Can NLPHL come back?
Relapsed or refractory NLPHL Treatment for NLPHL is usually effective. However, it can sometimes come back (relapse) and need more treatment. Occasionally, it doesn’t respond well to initial treatment (refractory lymphoma).