Table of Contents
What is miconazole nitrate gel?
MICONAZOLE (mi KON a zole) is an antifungal medicine. It is used to treat certain kinds of fungal or yeast infections of the skin. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What is the mechanism of action of miconazole?
Mechanism of action Miconazole inhibits the synthesis of ergosterol, a major component of fungal cell membranes. This interferes with the barrier function of the membrane and with membrane-bound enzymes.
What is Miconazole Nitrate made of?
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid.
What is miconazole used for?
Vaginal miconazole is used to treat vaginal yeast infections in adults and children 12 years of age and older. Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.
How long does miconazole nitrate take to work?
Available in cream form. Use as directed. All MONISTAT® products can take up to 7 days to fully cure a yeast infection.
Which starting material is used for the synthesis of miconazole?
Preparation of Miconazole, 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl] imidazole (6). 2,4-dichlorophenylmethanol 4 (0.212 g, 1.2 mmol) was dissolved in CH2Cl2 (10 mL) and cooled at 0 °C.
What is the classification of miconazole nitrate?
Miconazole is in the imidazole family of medications.
What class of drug is miconazole?
Miconazole is in a class of antifungal medications called imidazoles. It works by stopping the growth of fungi that cause infection.
How long do I leave miconazole in?
Use this medicine at bedtime, unless otherwise directed by your doctor. The vaginal tampon form of miconazole should be left in the vagina overnight and removed the next morning. This medicine is usually inserted into the vagina with an applicator.
What are the physical properties of miconazole?
Miconazole (T3D2988)
| Record Information | |
|---|---|
| Physical Properties | |
| State | Solid |
| Appearance | White powder. |
| Experimental Properties | Property Value Melting Point 159-163°C Boiling Point Not Available Solubility 1g/100mL (20°C) LogP 6.1 |
How do I know miconazole is working?
You should definitely feel some improvement within the first 3 days after starting miconazole (Monistat) and completely better within 7 days. If you don’t feel any improvement within 3 days or you are still having symptoms over a week later, please contact your healthcare provider.
What is the use of miconazole nitrate oral gel?
Miconazole Nitrate oral gel is indicated- For the treatment of oral and gastrointestinal candidiasis. For eradication of fungal colonization in the mouth and gastrointestinal tract. For the treatment of super infections due to gram-positive bacteria.
What is the half life of miconazole oral gel?
The absorbed portion of Miconazole oral gel is largely metabolized; less than 1% of the administered dose is excreted unchanged in the urine. The terminal plasma half-life is 20-25 hours in most patients.
What is the pharmacokinetics of miconazole?
Pharmacokinetics: The oral bioavailability of Miconazole is low (25-30%) because there is little absorption of Miconazole from the intestinal tract. Miconazole is systemically absorbed after administration as the oral gel. Absorbed Miconazole is bound to plasma proteins (88.2%), primarily to serum albumin and red blood cells (10.6%).
How do you take miconazole (oral) tablets?
Hold the tablet in place for 30 seconds. Switch sides of your mouth each day when you place miconazole (oral). Do not swallow whole. Do not chew, break, or crush. Either side of tablet may be placed next to the gum, but the rounded side may feel better. You may eat and drink when using miconazole (oral).