Table of Contents
What is the allometric exponent?
The allometric scaling exponent b (i.e., the slope) describes how the parameter of interest (Y) scales over different values of body weight (W) and defines the type of scaling relationship. This plot uses allometric scaling equation Y = 0.5 Â Wb as an example.
What is the allometric equation?
Allometric equations provide biomass estimates from tree measurements such as diameter at breast height (DBH), height, and/or wood density. These equations capture the scaling relationships between tree form and function to predict total and component (e.g., branch, needle, bark, bole, root) biomass [9].
What is an allometric equation?
Is Human growth allometric?
Humans are a good example of a species that undergoes allometric growth. The head, limbs, and body grow at different rates, resulting in a human adult with proportions completely different from those of the newborn baby: .
What is interspecies allometric scaling for dose conversion?
Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species.
Can we predict human clearance using single species allometric scaling?
However, the prediction appears less accurate when mouse, rat or dog data are used for single species allometric scaling. Human clearance is also well predicted using SA method with AFE < 2.0 for small-molecules renally excreted.
What is an example of an allometric scale?
Examples of Allometric Scaling Now let’s scale a single dose of 2.5mg in rat (body weight: 0.25kg) to humans (body weight=70kg) using allometric scaling principle. The scaled human Intake or oral dose will be: Scaled human dose (in mg) = 2.5 x (70/0.25)^ (3/4) = 170 mg
What is allometric scaling factor?
Allometric scalling factor is one of the uncertainty factors to consider addressing the differences between the experimental animal data and the human situation. European Chemicals Agency has calculated different allometric scaling factors for different species when compared to humans (see table below).