Table of Contents
What does CD44 mark?
In breast cancer research CD44+/CD24- expression is commonly used as a marker for breast CSCs and is used to sort breast cancer cells into a population enriched in cells with stem-like characteristics and has been seen as an indicator of increased survival time in epithelial ovarian cancer patients.
Which cells express Sca 1?
Cardiac progenitor cells (CPCs), which express Sca-1, are also found in human adult myocardium and the cells can divide and expand after myocardial infarction (Beltrami et al., 2001, 2003; Oh et al., 2003; Müller et al., 2005).
What is CD44 gene?
CD44 Gene – CD44 Molecule (Indian Blood Group) It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation…
Is CD44 extracellular?
The primary domains of CD44 are the extracellular domain (or ectodomain), the transmembrane domain, and the intracellular domain/cytoplasmic domain (Iczkowski, 2010). The extracellular domain interacts with the external microenvironment and senses stimuli in the external microenvironment (Underhill, 1992).
What is CD24 marker?
CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways.
Is stem cell antigen-1 (Sca-1) a candidate marker for cancer stem cells?
Cloned 20 years ago, stem cell antigen-1 (Sca-1) is used extensively to enrich for murine hematopoietic stem cells. The realization that many different stem cell types share conserved biochemical pathways has led to a flood of recent research using Sca-1 as a candidate marker in the search for tissue-resident and cancer stem cells.
What do stem cell markers tell us about colon cancer?
The cell surface proteins CD133, CD24 and CD44 are putative markers for cancer stem cell populations in colon cancer, associated with aggressive cancer types and poor prognosis. It is important to understand how these markers may predict treatment outcomes, determined by factors such as radioresistance.
Is cd44v9 a new marker of cancer stemness in solid tumors?
Recently CD44v9 has emerged as a novel marker of cancer stemness in a variety of solid tumors including HNSCC [72–77].
What is variant CD44 in lung adenocarcinoma?
Nishino M, Ozaki M, Hegab AE, et al. Variant CD44 expression is enriching for a cell population with cancer stem cell-like characteristics in human lung adenocarcinoma. J Cancer. 2017;8(10):1774–1785. doi: 10.7150/jca.19732.