Table of Contents
What is phentolamine mesylate used for?
Phentolamine mesylate (OraVerse), a nonselective a-adrenergic blocking drug, is the first therapeutic agent marketed for the reversal of soft-tissue anaesthesia and the associated functional deficits resulting from an intraoral submucosal injection of a local anaesthetic containing a vasoconstrictor.
What type of drug is phentolamine mesylate?
Phentolamine is an alpha adrenergic antagonist used to reverse soft tissue anesthesia. A nonselective alpha-adrenergic antagonist.
How do you give phentolamine mesylate?
Five milligrams of phentolamine mesylate (phentolamine mesylate) is then dissolved in 1 mL of Sterile Water for Injection. The dose for adults is 5 mg intramuscularly; for children, 3 mg. Blood pressure is recorded every 5 minutes for 30 to 45 minutes following injection.
How is phentolamine used for erectile dysfunction?
For the treatment of impotence: Adults— 0.5 to 1 milligram (mg) injected very slowly into the area of your penis as directed by your doctor. Allow one or two minutes to completely inject the dose.
How long does phentolamine last?
Peak serum concentrations of phentolamine are achieved within approximately 0.25 to 0.75 h after oral administration. The mean elimination half-life is approximately 2 h, and the duration of effect following administration is approximately 1–2 h.
Does phentolamine increase cardiac output?
1 Intravenously administered phentolamine provoked immediate decreases in diastolic blood pressure but increases in heart rate and cardiac output.
Is phentolamine used clinically?
Indications and Usage for Phentolamine Phentolamine Mesylate for Injection, USP is indicated for the prevention or control of hypertensive episodes that may occur in a patient with pheochromocytoma as a result of stress or manipulation during preoperative preparation and surgical excision.
How fast does phentolamine work?
This medicine usually begins to work in about 10 minutes. You should attempt intercourse within 2 hours after injecting the medicine. To reverse the effects of a soft-tissue anesthetic medicine, a dentist or other trained health professional will give you this medicine.
What is phentolamine mesylate?
Phentolamine mesylate, USP is a white or off-white, odorless crystalline powder with a molecular weight of 377.46. Its solutions are acid to litmus.
How much phentolamine mesylate should I take for erectile dysfunction?
It was an open-label study involving more than 2000 patients. Men received phentolamine mesylate 40 mg or 80 mg (10 tablets/month) as needed for up to 13 months and self-assessed erectile performance using two validated questionnaires.
What are the uses of phentolamine?
Uses of Phentolamine: 1 It is used during a test for pheochromocytoma . 2 It is used to treat high blood pressure due to pheochromocytoma. 3 It is used to treat skin problems from some drugs. 4 It is used to reverse the effects of some drugs. 5 It may be given to you for other reasons. Talk with the doctor.
Does phentolamine affect the parasympathetic system?
Phentolamine is a long-acting, adrenergic, alpha-receptor blocking agent which can produce and maintain “chemical sympathectomy” by oral administration. It increases blood flow to the skin, mucosa and abdominal viscera, and lowers both supine and erect blood pressures. It has no effect on the parasympathetic system.