Table of Contents
What is metastable form of drug?
Generally, metastable forms are more soluble than the corresponding stable polymorphic forms, but they transform to the more thermodynamically stable form in a relatively short time [14], and thus it is necessary to monitor the polymorphic transformation during formulation, manufacturing, and storage of dosage forms to …
Which drugs show polymorphism?
The most important properties during drug discovery and development include solubility, dissolution, bioavailability, and physical/chemical stability. The best known polymorphs showing a significantly different bioavailability in human study are chloramphenicol palmitate [5] and mefenamic acid [6].
Is metformin crystalline?
A multidrug crystal based on drug combinations was synthesized by the solvent evaporation method. This multicomponent crystal consisted of antidiabetic drugs Glimepiride (Gli) and Metformin (Met), which was performed by single crystal X-ray structure analysis.
Why is hydrochloride added to metformin?
It is also being studied in the treatment of cancer. Metformin hydrochloride decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body’s use of the glucose. It is a type of antidiabetic agent. Metformin is the active ingredient of metformin hydrochloride.
What is metastable state of polymorph?
Metastable polymorph Metastable state, in physics and chemistry, particular excited state of an atom, nucleus, or other system that has a longer lifetime than the ordinary excited states and that generally has a shorter lifetime than the lowest, often stable, energy state, called the ground state.
What is polymorph?
Polymorph (officially known as Polycaprolactone) is a biodegradable polyester that can be shaped and reshaped infinitely. It has a very low melting point of around 60°C – 62°C but when cool has physical properties of a very tough plastic, similar to nylon.
What are polymorphs give example?
Classical examples of polymorphism are the pair of minerals calcite and aragonite, both forms of calcium carbonate. Perhaps the most famous example is that of the polymorphs of carbon: graphite and diamond.
What is the structure of metformin?
C4H11N5Metformin / Formula
What type of compound is metformin?
Metformin is a member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1. It has a role as a hypoglycemic agent, a xenobiotic, an environmental contaminant and a geroprotector. It derives from a biguanide. It is a conjugate base of a metformin(1+).
What is metformin hydrochloride made of?
In addition to the active ingredient metformin hydrochloride, each tablet contains the following inactive ingredients: candellila wax, cellulose acetate, hypromellose, magnesium stearate, polyethylene glycols (PEG 400, PEG 8000), polysorbate 80, povidone, sodium lauryl sulfate, synthetic black iron oxides, titanium …
What is metformin hydrochloride made out of?
Metformin hydrochloride is a hydrochloride resulting from the reaction of metformin with one molar equivalent of hydrogen chloride. It has a role as an environmental contaminant, a hypoglycemic agent and a xenobiotic. It contains a metformin(1+).
What is a metastable level?
Metastable state, in physics, is the particularly excited energy level or higher energy level of an atom, nucleus, or other systems that have a longer lifetime than the ordinary excited states (or the energy levels) and that generally has a shorter lifetime than the lowest, often highly stable, energy state is known as …
What is meant by polymorph?
Definition of polymorph 1 : a polymorphic organism also : one of the several forms of such an organism. 2 : any of the crystalline forms of a polymorphic substance.
Why is polymorph used?
Polymorph is used for: Manufacturing awkward shapes such as ergonomic handles. Joining components together. making moulds for vacuum forming.
What is an example of a polymorph?
Some common examples of polymorphs are calcite and aragonite. The composition of these two minerals is CaCO3, but calcite is rhombohedral while aragonite is orthorhombic. Diamond and graphite , both of which are pure carbon , are also polymorphs. Diamond, however, is cubic while graphite is hexagonal.
What are the two types of polymorphs?
Types of Polymorphism
- Subtype polymorphism (Runtime) Subtype polymorphism is the most common kind of polymorphism.
- Parametric polymorphism (Overloading)
- Ad hoc polymorphism (Compile-time)
- Coercion polymorphism (Casting)
What are polymorphs in medicine?
Polymorphism: A variation in the DNA that is too common to be due merely to new mutation. A polymorphism must have a frequency of at least 1% in the population. Examples of polymorphisms include the genes for sickle cell disease, thalassemia and G6PD deficiency.