Table of Contents
What is Pluronic lecithin Organogel?
Pluronic lecithin organogel is a microemulsion-based gel that has been effectively used by physicians and pharmacists to deliver hydrophilic and lipophilic drugs topically and transdermally across the stratum corneum.
What does PLO gel stand for?
Invented in the early 1990s as an alternative to oral medications, PLO stands for Pluronic Lecithin Organogel, a mixture of oil and water that thickens to form a gel. The PLO gel can be applied to the skin at the site of the pain or to the inside of the wrist for a full-body effect.
Is PLO gel aqueous?
Usually it is made up of two phase, first pluronic gel (aqueous phase) and second lecithin phase (oil phase), i.e. pluronic gel combined with a lecithin phase. PLO gels formed are liquid (sol) at cold temperatures and undergo a phase change (gel) when the temperature is elevated.
What is Diffusimax?
Diffusimax is pluronic lecithin organogel, often abbreviated as PLO gel. It is a liposomal base that is used as a vehicle for preparing a wide range of topical formulations.
How does PLO gel penetrate the skin?
Topical compounds in PLO differ from other types of topical creams, gels or ointments in that they generally work systemically rather than locally. This means that when applied, medications incorporated in PLO gel should penetrate the skin to allow absorption by the bloodstream.
What is Pluronic acid?
Pluronics, also known as poloxamers, are a class of synthetic block copolymers which consist of hydrophilic poly(ethylene oxide) (PEO) and hydrophobic poly(propylene oxide) (PPO), arranged in an A-B-A triblock structure, thus giving PEO-PPO-PEO (Fig.
What is Pluronic F108?
Pluronic® F108 is a tri block copolymer and a terminal primary dihydroxy-functional oligomer. It behaves as a nonionic surfactant. It is a surface active material whose properties are dependent on the hydrophilic (EO)/hydrophobic (PO) ratio. High EO content gives better o/w stabilizers.
How do you make diclofenac in PLO gel?
Directions:
- Weigh diclofenac powder and PLO gel.
- Dissolve diclofenac powder in alcohol.
- Gradually add small amounts of PLO gel to diclofenac powder and levigate until completely mixed.
- Transfer to final container and label.
What is Lipoderm cream used for?
Lipoderm® has been used to transdermally deliver medications for pain, nausea & for veterinary use. When used for pain, multiple drugs can be combined to target the different causes of pain2. Lipoderm® is very effective at delivering drugs to cats through the skin in the inner ear3.
What is PCCA Lipoderm base used for?
Lipoderm is the ideal base for deep-penetrating topical formulations for local and systemic absorption of active pharmaceutical ingredients (APIs).
What is VersaPro cream used for?
With its smooth, fluid texture and non-greasy after feel, MEDISCA’s VersaPro™ Lotion Base is well suited for both cosmetic and dermatological applications. It offers a wide pH stability range and features a thinner consistency making it ideal for compounding higher concentrations of hormones.
How do you make a Pluronic solution?
Dissolve 2 g of Pluronic F-127 in 10 mL of anhydrous dimethylsulfoxide (DMSO) to give a 20% (w/v) stock solution. This may require heating at ~40° for about 20 minutes. Store both solid and solution at room temperature.
How do you use Pluronic?
Guidelines for Use 1. Dissolve 1 g of Pluronic® F-127 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Pluronic® F-127 in 10 mL of anhydrous dimethyl sulfoxide (DMSO) to make a 20% (w/v) stock solution. These may require heating from 40 to 50 °C for about 30 minutes.
What is diclofenac 10% in PLO gel?
Diclofenac is used to treat pain and other symptoms of arthritis of the joints (eg, osteoarthritis), such as inflammation, swelling, stiffness, and joint pain. However, this medicine does not cure osteoarthritis and will help you only as long as you continue to use it.
What are the ingredients in Lipoderm?
We recommend
- Ketamine Hydrochloride 10%, Gabapentin 10%, and Ketoprofen 10% in Lipoderm.
- Fluoxetine Hydrochloride 5 mg/0.1 mL in Pluronic Lecithin Organogel.
- Amitriptyline HCl 2%, Ketamine HCl 1%, and Lidocaine HCl 5% in PLO Gel.
- Fluoxetine Hydrochloride 5 mg/g in Lipoderm Transdermal Base.