Table of Contents
Does HER2 bind to EGFR?
Contrary to other ERBB family members, HER2 does not directly bind to any known ligands. Instead, activation of HER2-mediated signaling pathways occurs by heterodimerization with ligand-activated EGFR or ERBB3, or by homodimerization when it is present in high concentrations, such as in cancer (26, 86).
Is trastuzumab a EGFR inhibitor?
5a, EGFR was not phosphorylated in CHO-EGFR cells, and addition of EGF stimulated the phosphorylation of EGFR. Treatment with trastuzumab was not able to inhibit EGF-induced EGFR phosphorylation. Moreover, trastuzumab by itself did not have any detectable effects on EGFR phosphorylation in CHO-EGFR cells.
Is Herceptin an EGFR inhibitor?
Inactivation of epidermal growth factor receptor (EGFR) family members represents a promising strategy for the development of selective therapies against epithelial cancers. Current anti-EGFR therapies, such as cetuximab (Erbitux), gefitinib (Iressa), or trastuzumab (Herceptin), target EGFR or HER-2 but not both.
What type of receptor is EGFR?
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane proteins are activated following binding with peptide growth factors of the EGF-family of proteins.
What is difference between eGFR and GFR?
GFR is Glomerular Filtration Rate and it is a key indicator of renal function. eGFR is estimated GFR and is a mathematically derived entity based on a patient’s serum creatinine level, age, sex and race.
Is trastuzumab a EGFR?
What does HER2 stand for?
Introduction The tyrosine kinase human epidermal growth factor receptor 2 (HER2, also ErbB2) belongs to the epidermal growth factor receptor (EGFR) family, consisting of EGFR, HER2, HER3 and HER4 [1]. HER2 represents an overexpressed oncoprotein responsible for approximately 20% of all breast cancer cases [2,3].
Is EGFR or HER2 expression higher in Her2 driven breast cancer?
In SKBR3 cells, an immortalized breast cancer cell line serving as a common model for HER2 driven breast cancer, HER2 expression is 20-fold higher in average compared to EGFR [15,16]. In vitro studies in this cell line reported therapy resistance development to trastuzumab upon EGFR overexpression [17].
Do EGFR and HER2 receptors differ on LMPs of different regions?
The number of HER2 receptors on LMPs of EGFR-enriched cells was slightly reduced when compared to LMPs of bulk cells, whereas their expression on the clustered regions was comparable (Supplemental Figure S8and Table 1). The lowest number of EGFR and HER2 receptors were found on bulk flat regions (Supplemental Figure S9and Table 1).
What is the HER2 heterodimerization?
HER2 is an orphan receptor that is activated ligand-independently by homodimerization. In addition, HER2 is able to heterodimerize with EGFR, HER3, and HER4. Heterodimerization has been proposed as a mechanism of resistance to therapy for HER2 overexpressing breast cancer.