Table of Contents
What is Periungual fibroma?
Periungual fibromas are rare benign dermatologic lesions that may be acquired or associated with tuberous sclerosis or von Recklinghausen’s disease. Periungual fibromas may place excessive pressure on the nail matrix, resulting in the potential for extensive nail pathologic conditions and pain.
What causes Periungual fibroma?
Multiple periungual fibromas are a rare form of benign tumors composed of connective tissue. Patients can acquire periungual fibromas but they are most commonly a consequence of tuberous sclerosis complex. These benign tumors often put excessive pressure on the nail matrix, causing pain, discomfort and nail deformity.
How is Periungual fibroma treated?
Periungual fibromas are most often treated by surgical resection, with a high recurrence rate. Other authors have used CO 2 laser8 or electrodesiccation. The main problem of these treatments is that the conservation of proximal fold and the integrity of nail plate are not always possible.
Is fibroma a benign tumor?
What is a fibroma? A fibroma is typically a benign fibroid or fibroid tumor. Fibromas are composed of fibrous, or connective, tissue.
What is Bourneville disease?
A rare neurocutaneous disorder characterized by multisystem hamartomas, most commonly involving the skin, brain, kidneys, lungs, eye, and heart, and associated with neuropsychiatric disorders.
What is TSC1 and TSC2?
TSC1 and TSC2 are disease genes for tuberous sclerosis complex (TSC), a neurocutaneous disorder in which hamartomas and other benign tumors form in many organs including brain, skin, and kidneys. Neurological manifestations including autism, intellectual disability, and epilepsy are also common.
What is Epiloia?
Epiloia is more commonly known as tuberous sclerosis (TS) or tuberous sclerosis complex (TSC), a genetic disorder that is characterized by non-cancerous marks or malformations in many organs, but particularly the skin, brain, eye, kidney and heart.
What tumor is associated with tuberous sclerosis?
Kidney tumors are common in people with tuberous sclerosis complex; these growths can cause severe problems with kidney function and may be life-threatening in some cases. Additionally, tumors can develop in the heart (cardiac rhabdomyoma) and the light-sensitive tissue at the back of the eye (the retina ).
Is TSC genetic?
Tuberous sclerosis complex is a genetic disorder characterized by the growth of numerous noncancerous (benign) tumors in many parts of the body. These tumors can occur in the brain, kidneys, heart, skin, and other organs, in some cases leading to significant health problems.
Are fibromas malignant?
A fibroma is typically a benign fibroid or fibroid tumor.
What is periungual fibroma (PF)?
To the editor: Periungual fibroma (PF) is a cutaneous manifestation of tuberous sclerosis complex (TSC). Although a benign tumor, it can bleed, cause pain, and distort the nail.
How are periungual fibromas of Koenen tumors studied histologically?
Fifteen periungual fibromas from nine patients were studied histologically. The lesions were elongated. Capillaries were found in the distal part surrounded by thin collagen bundles whereas the proximal part was made up of dense, closely packed fibers. The epidermis covering the tumor appeared to be … Histopathologic study of Koenen tumors.
What are non-traumatic peripheral fungal lesions?
Although a benign tumor, it can bleed, cause pain, and distort the nail. Non-traumatic PFs are among the major diagnostic criteria of tuberous sclerosis complex (TSC). 1 The lesions usually develop post-puberty, are more common on toenails than on fingernails, and occur more frequently in women than in men. 2, 3